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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >The Upper Digestive Tract Microbiome and Oesophageal Squamous Cell Carcinoma: Epidemiology, Pathogenesis, and Clinical Implications in Africa
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The Upper Digestive Tract Microbiome and Oesophageal Squamous Cell Carcinoma: Epidemiology, Pathogenesis, and Clinical Implications in Africa

机译：上消化道微生物组和食管鳞状细胞癌：流行病学，发病机制和非洲的临床意义

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摘要

The study of the microbiome has significantly contributed to our understanding of complex diseases including cancer, with a profound influence of the microbiota on clinical prognosis and the efficacy of cancer treatments. Oesophageal cancer is positioned amongst the most aggressive malignant diseases, resulting from a complex interaction between anthropometric, genetic, immune response, and environmental factors. Oesophageal squamous cell carcinoma (OSCC) is the most common type of oesophageal cancer and is a serious burden in Eastern Africa, in the area known as the African oesophageal cancer corridor (AOCC). OSCC is often diagnosed at a late stage, with patients already suffering from severe malnutrition and dehydration due to swallowing difficulties, leading to high mortality rates. So far, aetiological factors have been individually analysed with an inappropriate contextualisation. The upper digestive tract microbiome has been proposed to contribute to the onset and progression of OSCC but with limited understanding of the mechanisms behind this interaction. Data on African populations are limited, and the aetiology of AOCC is still poorly understood. This review discusses the current knowledge of the aetiology of OSCC in Africa, with special focus on the probable influence of the upper digestive tract microbiota.
机译：微生物组的研究极大地促进了我们对包括癌症在内的复杂疾病的理解，微生物组对临床预后和癌症治疗的疗效有着深远的影响。食管癌是最具侵袭性的恶性疾病之一，是人体测量、遗传、免疫反应和环境因素之间复杂相互作用的结果。食管鳞状细胞癌（OSCC）是最常见的食管癌类型，在非洲东部的非洲食管癌走廊（AOCC）地区是一个严重的负担。OSCC通常在晚期诊断，患者因吞咽困难已经严重营养不良和脱水，导致高死亡率。到目前为止，病因学因素已被单独分析，并采用了不恰当的语境。有人认为上消化道微生物群有助于OSCC的发生和发展，但对这种相互作用背后的机制了解有限。关于非洲人口的数据有限，对AOCC的病因仍知之甚少。本综述讨论了非洲口腔鳞状细胞癌病因的最新知识，特别关注上消化道微生物群的可能影响。

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