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首页> 外文期刊>Analytical methods >Simple and rapid determination of loratadine in pharmaceuticals using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode
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Simple and rapid determination of loratadine in pharmaceuticals using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode

机译：使用方波伏安法和阴极预处理的硼掺杂金刚石电极简单快速地测定药物中的氯雷他定

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摘要

The electrochemical behavior and determination of antihistaminic drug loratadine using a cathodically pretreated boron-doped diamond electrode (BDDE) are proposed. This is the first voltammetric method using a carbon-based electrode material. The anodic peak potential for loratadine at the BDDE was 1.67 V (vs. Ag/AgCl (3.0 mol L-1 KO)) by cyclic voltammetry in a 0.50 mol L-1 HClO4 solution, whereas at the glassy carbon electrode (GCE), no peak potential was observed, due to the narrow potential window of this electrode. Using the square-wave voltammetric technique (f = 50 Hz, a = 40 mV and AEs = 2 mV), the obtained analytical curve was linear for loratadine concentrations ranging from 0.98 to 19 mu mol L-1 This simple, rapid and green analytical method was successfully applied to the determination of loratadine in pharmaceutical formulations. The results were in close agreement, with a 95% confidence level, with those obtained using comparative spectrophotometric method.
机译：提出了使用阴极预处理的掺硼金刚石电极（BDDE）的抗组胺药物氯雷他定的电化学行为和测定。这是使用碳基电极材料的第一种伏安法。在0.50 mol L-1 HClO4溶液中，通过循环伏安法测定的BDDE中氯雷他定的阳极峰电位为1.67 V（vs。Ag / AgCl（3.0 mol L-1 KO）），而在玻碳电极（GCE）处，由于该电极的电势窗口较窄，因此未观察到峰值电势。使用方波伏安法（f = 50 Hz，a = 40 mV，AEs = 2 mV），所获得的分析曲线对于氯雷他定浓度为0.98至19μmolL-1呈线性。这种简单，快速且绿色的分析方法方法成功地用于药物制剂中氯雷他定的测定。结果与使用比较分光光度法获得的结果非常一致，置信度为95％。

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