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The influence of early exposure to methylphenidate on addiction-related behaviors in mice

机译：早期接触甲基酚对小鼠成瘾相关行为的影响

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摘要

Methylphenidate (MET) has a putative cognitive enhancer effect that has led adolescents and young adults to increase and indiscriminate its use aiming to ameliorate their productivity. However, the impacts of MET on addiction-related behaviors, emotional levels, and cognition are still not fully understood. To investigate the influence of chronic treatment with MET during adolescence on addiction-like behaviors, memory, and anxiety in adult mice. Thirty-day-old female mice received i.p. 10 mg/kg MET or Veh injections for 10 consecutive days. Forty days after the treatment (mice were 70-days-old), animals were submitted to the behavioral evaluation under the effects of MET, which included: MET-induced conditioned place preference (CPP), behavioral sensitization, and plus-maze discriminative avoidance task. Pre-exposure to MET during adolescence promoted an early expression of CPP and also facilitated the development of MET-induced behavioral sensitization during adulthood. These addictive-like behaviors were accompanied by anxiogenic effects of MET but not by any memory-enhancing effect. We demonstrated that exposure to MET during adolescence can increase the vulnerability to addiction-like behaviors and anxiety during adulthood. Our results reinforce the necessity of a more efficient system to control MET indiscriminate use, thus avoiding its potential tardive addictive effects.
机译：哌甲酯（Methylphenidate，Methylphenidate，MET）具有一种公认的认知增强效应，导致青少年和年轻人增加和不加区分地使用它，以改善他们的生产力。然而，MET对成瘾相关行为、情绪水平和认知的影响仍不完全清楚。研究青春期长期服用MET对成年小鼠成瘾样行为、记忆和焦虑的影响。30日龄雌性小鼠连续10天注射10 mg/kg MET或Veh。治疗40天后（小鼠70日龄），将动物提交给MET影响下的行为评估，包括：MET诱导的条件性位置偏爱（CPP）、行为敏化和加迷宫辨别性回避任务。青春期预暴露于MET促进了CPP的早期表达，也促进了成年期MET诱导的行为敏化的发展。这些成瘾性行为伴随着MET的焦虑效应，但没有任何记忆增强效应。我们证明，青春期接触MET会增加成年期成瘾行为和焦虑的易感性。我们的研究结果进一步证明，有必要建立一个更有效的系统来控制甲基苯丙胺的滥用，从而避免其潜在的迟发性成瘾效应。

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