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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration
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Measuring attention in rats with a visual signal detection task: Signal intensity vs. signal duration

机译：用视觉信号检测任务的大鼠测量注意：信号强度与信号持续时间

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摘要

Measurement of attentional performance in animal behavioral research allows us to investigate neural mechanisms underlying attentional processes and translate results to better understand human attentional function, dysfunction and drug treatments to reverse dysfunction. One useful method to measure attention in experimental animal studies is to use an operant visual signal detection paradigm, consisting of two levers and the rapid flashing of a cue lamp to signal a reward. In this study, we tested the relative sensitivity of this task when using different variants of the stimulus signal, varying brightness or duration of the light cue. To investigate roles of different neural systems underlying attentional processes, we assessed the sensitivity of attentional performance with these two different cue variations with blockade of muscarinic acetylcholine and NMDA glutamate receptors with scopolamine and MK-801 (dizocilpine). Operant signal detection was tested using a signal light that varied in intensity (0.027, 0.269, 1.22 lx) of the signal light or in a paradigm which varied the duration (0.5 s, 1 s, 2 s) of the signal light. Both methods of assessing attention showed construct validity for producing gradients of accuracy for signal detection; the dimmest cue led to less accurate responding compared to the brighter cues, and the shortest duration led to less accuracy compared to the longer durations. However, the tests differed in their sensitivity to pharmacological disruption. With the duration test, the high dose of MK-801 along with coexposure of scopolamine and MK-801 caused a significant reduction of hit and rejection accuracy. Conversely, the intensity variation test did not show significant differences as a function of drug exposures. These data suggest that changes in signal duration, rather than signal intensity, during operant signal detection may have higher sensitivity to detecting drug effects and be a more useful technique for examining pharmacological interventions on attentional behavior and performance.
机译：动物行为研究中注意力表现的测量使我们能够研究注意力过程的神经机制，并将结果转化为更好地理解人类的注意力功能、功能障碍和逆转功能障碍的药物治疗。在实验动物研究中，测量注意力的一种有用方法是使用操作性视觉信号检测范式，该范式由两个杠杆和快速闪烁的提示灯组成，以发出奖励信号。在这项研究中，我们测试了当使用不同的刺激信号变体、不同的亮度或光线索的持续时间时，这项任务的相对敏感性。为了研究不同神经系统在注意过程中的作用，我们用东莨菪碱和MK-801（地唑西平）阻断毒蕈碱乙酰胆碱和NMDA谷氨酸受体，评估了这两种不同线索变化对注意表现的敏感性。使用信号光强度（0.027,0.269,1.22 lx）变化的信号光或信号光持续时间（0.5 s,1 s,2 s）变化的范例测试操作性信号检测。这两种评估注意的方法都显示出结构效度，可以产生信号检测的准确度梯度；与明亮的提示相比，最暗的提示导致较不准确的反应，与较长的持续时间相比，最短的持续时间导致较不准确的反应。然而，这些试验对药物破坏的敏感性不同。在持续时间试验中，高剂量的MK-801以及东莨菪碱和MK-801的共同暴露导致命中率和排斥率显著降低。相反，强度变化试验并未显示出与药物暴露相关的显著差异。这些数据表明，在操作性信号检测期间，信号持续时间的变化，而不是信号强度的变化，可能对检测药物效应具有更高的敏感性，并且是检查药物干预对注意行为和表现的更有用的技术。

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