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Postoperative inpatient utilization of opioid and opioid-sparing analgesics in the United States hospitals, 2007-2017

机译:美国医院阿片类药物和阿片类药物备受镇痛药的术后住院治疗,2007 - 2017年

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Purpose: To evaluate recent trends in inpatient postoperative utilization of opioid and non-opioid analgesics in US hospitals. Methods: Using Premier Research database (October 2007-September 2017), we identified adults who were hospitalized for inpatient surgical procedures [N = 6 068 133). For each month, we calculated proportion of patients admitted that month who were administered (1) opioids, (2) acetaminophen, (3) non-steroidal anti-inflammatory drugs (NSADs), and (4) gabapentinoids (gabapentin or pregabalin) during the postoperative period, defined as inpatient postoperative days 1-7, unless discharged earlier. For patients administered opioids, we estimated total and average daily postoperative opioid dose in morphine milligram equivalents (MMEs). Monthly measures were standardized to the distribution of surgeries and the length of postoperative stay within each surgery during the last year of available data. Results: Overall, 90.8% of patients were administered opioids postoperatively; mean total postoperative dose was 304 MMEs (median 130). Both the frequency and the amount of opioids administered remained stable over 2007-2017. Postoperative use of acetaminophen increased from mean standardized monthly prevalence of 78% in 2007-2008 to 85% in 2017, while the use of NSAIDs remained stable at a standardized mean of 37%. The use of gabapentinoids increased from below 10% in 2007-2008 to the mean standardized monthly prevalence of 23% in 2017. Conclusion: Despite growing awareness of risks associated with postoperative opioid use, we observed no change in postoperative utilization of opioids in US hospitals. Increasing the use of non-opioid pain management approaches could constitute an important target in our efforts to curtail US opioid epidemic.
机译:目的:评估美国医院住院患者术后使用阿片类和非阿片类镇痛药的近期趋势。方法:使用Premier研究数据库(2007年10月至2017年9月),我们确定了因住院手术而住院的成年人[N=6 068 133]。我们计算了每个月接受(1)阿片类药物,(2)对乙酰氨基酚,(3)非甾体抗炎药(NSAD)和(4)加巴喷丁类药物(加巴喷丁或普瑞巴林)治疗的患者比例术后期间,定义为住院患者术后1-7天,除非提前出院。对于服用阿片类药物的患者,我们以吗啡毫克当量(MMEs)估计术后阿片类药物的总剂量和平均每日剂量。根据可用数据的最后一年,每个月对手术的分布和每次手术的术后住院时间进行标准化。结果:总体而言,90.8%的患者术后服用阿片类药物;术后平均总剂量为304 MMEs(中位数130)。2007-2017年期间,阿片类药物的使用频率和数量保持稳定。术后对乙酰氨基酚的使用率从2007-2008年的平均标准化月患病率78%增加到2017年的85%,而非甾体抗炎药的使用率保持在37%的标准化平均水平。加巴喷丁类药物的使用从2007-2008年的10%以下增加到2017年的平均标准化月患病率23%。结论:尽管人们越来越意识到术后使用阿片类药物的风险,但我们观察到美国医院术后使用阿片类药物的情况没有变化。增加非阿片类药物疼痛管理方法的使用可能是我们遏制美国阿片类药物流行的一个重要目标。

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