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首页> 外文期刊>Behavioural Brain Research: An International Journal >Maternal separation facilitates extinction of social fear in adult male mice
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Maternal separation facilitates extinction of social fear in adult male mice

机译：母体分离有助于消除成年雄性小鼠的社交恐惧感

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摘要

Early life stress, such as child abuse or neglect, is a risk factor for the development of psychopathologies characterized by abnormal social and emotional behaviors. In rodents, long-lasting changes in stress coping and emotional behavior can be induced by separating pups from their mother. We used maternal separation (MS; 3 h daily on postnatal days 1-14) to test whether early life stress alters acquisition and extinction of social fear in adult male mice as studied in a specific model of social fear, i.e., in the social fear conditioning paradigm. We show that MS facilitated extinction of social fear without altering acquisition or expression of social fear. This facilitatory effect of MS on social fear extinction was not due to improved social learning and memory abilities or to increased social interest, as MS rather impaired social memory in the social discrimination test and did not alter social preference in the social preference-avoidance test. In contrast, MS did not alter acquisition and extinction of non-social, cued fear, or non-social memory as assessed in the object discrimination test and non-social anxiety as assessed in the elevated plus-maze. These results suggest that a social stress like MS in early life may improve coping with and recovery from a traumatic social experience in adulthood in mice. (C) 2015 Elsevier B.V. All rights reserved.
机译：早期的生活压力，例如虐待或忽视儿童，是发展以异常的社交和情感行为为特征的精神病学的危险因素。在啮齿动物中，通过将幼犬与母亲分开，可以引起压力应对和情绪行为的长期变化。我们使用母体分离（MS;在出生后1-14天每天3小时）测试早期生活压力是否会改变成年雄性小鼠的社交恐惧感的获得和消退，这是在特定的社交恐惧感模型（即社交恐惧感）中进行的研究条件范式。我们表明，MS促进了社会恐惧感的消灭，而没有改变社会恐惧感的获得或表达。 MS对社会恐惧消灭的促进作用不是由于社会学习和记忆能力的提高或社会兴趣的增加，因为MS在社会歧视测试中相当程度地损害了社会记忆，并没有在避免社交偏好的测试中改变社会偏好。相比之下，MS并没有改变对象辨别测试中评估的非社交，暗示的恐惧或非社交记忆的获取和消灭，以及高迷宫评估的非社交焦虑的获取和消灭。这些结果表明，像MS这样在早年生活中的社交压力可能会改善小鼠成年后的创伤性社交经历并从中恢复。 （C）2015 Elsevier B.V.保留所有权利。

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