Synthesis and antibacterial properties of quaternary ammonium derivative of polyethylenimine

Kwolek Urszula; Wojcik Kinga; Janiczek Malgorzata; Nowakowska Maria; Kepczynski Mariusz

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Synthesis and antibacterial properties of quaternary ammonium derivative of polyethylenimine

机译：聚乙烯亚胺季铵衍生物的合成及抗菌性能

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摘要

The quaternary derivative of branched polyethylenimine (bPEI-met) was synthesized and its antibacterial activity against Gram-positive bacterium (Staphylococcus aureus) and Gram-negative bacterium (Escherichia coli) was studied. The values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of bPEI-met against mentioned bacteria were determined. These indicated that bPEI-met could be considered as an effective alternative to antibiotics for the treatment of selected bacterial strains. The results obtained can be useful in search for drugs allowing treatment of antibiotic resistant bacterial strains.

机译：合成了支化聚乙烯亚胺（bPEI-met）的四元衍生物，并研究了其对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）的抗菌活性。测定了bPEI-met对上述细菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。这表明，bPEI-met可被视为治疗特定菌株的抗生素的有效替代品。所得结果可用于寻找治疗抗生素耐药菌株的药物。

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来源
《Polimery》 |2017年第4期|共6页
作者
Kwolek Urszula; Wojcik Kinga; Janiczek Malgorzata; Nowakowska Maria; Kepczynski Mariusz;
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作者单位

Jagiellonian Univ Fac Chem Ingardena 3 PL-30060 Krakow Poland;

Jagiellonian Univ Fac Biochem Biophys &

Biotechnol Dept Microbiol Gronostajowa 7 PL-30387 Krakow Poland;

Jagiellonian Univ Fac Chem Ingardena 3 PL-30060 Krakow Poland;

Jagiellonian Univ Fac Chem Ingardena 3 PL-30060 Krakow Poland;

Jagiellonian Univ Fac Chem Ingardena 3 PL-30060 Krakow Poland;

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原文格式 PDF
正文语种 eng
中图分类高分子化合物工业（高聚物工业）;
关键词
polyethylenimine; polycation; liposomes; minimum inhibitory concentration; minimum bactericidal concentration;

机译：聚乙烯;聚丙烯;脂质体;最小抑制浓度;最小杀菌浓度;

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Synthesis and antibacterial properties of quaternary ammonium derivative of polyethylenimine

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