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首页> 外文期刊>Behavioural Brain Research: An International Journal >The role of lateral septal NK1 receptors in mediating anxiogenic effects induced by intracerebroventricular injection of substance P.
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The role of lateral septal NK1 receptors in mediating anxiogenic effects induced by intracerebroventricular injection of substance P.

机译：侧隔NK1受体在介导脑室内注射P物质诱导的焦虑发生作用中的作用。

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摘要

The lateral septal nucleus (LS) presents a dense plexus of fibers containing substance P (SP), which is known to induce pronounced anxiogenic-like effects when applied into this brain site. In the present report, we investigated the role of lateral septal NK(1) receptors in mediating the pro-aversive effects resulting from intracerebroventricular (i.c.v.) injection of SP in rats observed in the elevated plus-maze (EPM) test. Our results show that FK888, a selective NK(1) receptor antagonist, injected into the LS inhibited the anxiogenic-like responses induced by SP i.c.v. injections, whereas the treatment with FK888 into the LS did not alter 'per se' the parameters recorded in the EPM test when compared to the control group that received physiological buffer solution into the LS and lateral ventricle. Thus, our data suggest that the anxiogenic-like responses induced by SP centrally injected are, to a large extent, mediated by NK(1) receptors in the LS.
机译：外侧中隔核（LS）呈现出一种密集的含有P物质（SP）的纤维丛，当将其施加到该大脑部位时会引起明显的类似焦虑症的作用。在本报告中，我们调查了侧隔NK（1）受体在介导大鼠脑室内（i.c.v.）注射SP引起的促平均作用中的作用。我们的结果表明，注射入LS的FK888，一种选择性的NK（1）受体拮抗剂，抑制了SP i.c.v诱导的类似焦虑的反应。与将生理缓冲溶液注入LS和侧脑室的对照组相比，注射FK888对LS进行的治疗并未“本身”改变EPM测试中记录的参数。因此，我们的数据表明，集中注射的SP诱导的焦虑发生反应在很大程度上是由LS中的NK（1）受体介导的。

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