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首页> 外文期刊>Polymers for advanced technologies >Impact of supramolecular interactions on swelling and release behavior of UPy functionalized HEMA-based hydrogels
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Impact of supramolecular interactions on swelling and release behavior of UPy functionalized HEMA-based hydrogels

机译：超分子相互作用对UPY官能化血清水凝胶肿胀和释放行为的影响

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摘要

Supramolecular polymeric hydrogels based on copolymers of 2-hydroxyethyl methacrylate (HEMA) and HEMA functionalized with ureidopyrimidinone (quadruple H-bonding motifs and HU comonomer) were prepared at different HU comonomer ratios (PH-Sn, n=HU mol%). For comparison, HEMA homopolymers (PH-Cn, n=mol% of a chemical cross-linker) were synthesized. In contrast to PH-S0, PH-Sn copolymers act like cross-linked hydrogels and absorb large amounts of water while retaining shape. Viscosities of the hydrogels decreased, and elastic and loss moduli increased with increasing HU content. Compression modulus of the swollen PH-Sn hydrogels increased with HU content and varied between 54 and 240kPa. Study of metronidazole loading/release behaviors of PH-S6 hydrogel against PH-C6 revealed a negligible burst effect for the former and a sustained release that continued for about 120hours. We conclude that modification of poly(2-hydroxyethyl methacrylate) with HU through urethane linkages is an effective strategy to developing physical hydrogels with predictable behavior for biomedical applications.
机译：以甲基丙烯酸2-羟乙基乙酯（HEMA）和脲嘧啶酮（四重氢键基序和HU共聚单体）官能化的HEMA共聚物为基础，在不同的HU共聚单体比例（PH-Sn，n=HU-mol%）下制备了超分子聚合物水凝胶。为了进行比较，合成了HEMA均聚物（PH Cn，n=化学交联剂的摩尔百分比）。与PH-S0相比，PH-Sn共聚物的作用类似于交联水凝胶，在保持形状的同时吸收大量水分。随着HU含量的增加，水凝胶的粘度降低，弹性模量和损耗模量增加。溶胀的PH-Sn水凝胶的压缩模量随着HU含量的增加而增加，在54到240kPa之间变化。对PH-S6水凝胶对PH-C6的甲硝唑负载/释放行为的研究表明，前者的爆破效应可忽略不计，持续释放约120小时。我们的结论是，通过氨基甲酸乙酯键对聚（2-羟乙基甲基丙烯酸酯）进行HU修饰是开发具有可预测性能的物理水凝胶用于生物医学应用的有效策略。

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