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PEGylated poly(ester amide) elastomer scaffolds for soft tissue engineering

机译：用于软组织工程的聚乙二醇化聚（酯酰胺）弹性体支架

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Biodegradable synthetic elastomers with tunable mechanical and physicochemical properties remain attractive materials for soft tissue engineering. We have recently synthesized novel poly(1,3-diamino-2-hydroxypropane-co-glycerol sebacate)-co-poly(ethylene glycol) (APS-co-PEG) biodegradable elastomers. This class of PEGylated elastomers has widely tunable mechanical and degradation properties compared wtih currently available biodegradable elastomers. To further investigate the biological application of this class of elastomers, we fabricated hybrid APS-co-PEG/polycaprolactone (PCL) porous scaffolds by electrospinning. The fiber morphology, chemical composition, mechanical properties, degradability, and cytocompatibility of hybrid APS-co-PEG/PCL electrospun scaffolds were characterized. These scaffolds exhibited a wide range of mechanical properties and similar cytocompatibility to PCL scaffolds. Importantly, PEGylation inhibited platelet adhesion on all APS-co-PEG/PCL electrospun scaffolds when compared with PCL and APS/PCL scaffolds, suggesting a potential role in mitigating thrombogenicity in vivo. Additionally, APS-25PEG/PCL scaffolds were found to be mechanically analogous to human heart valve leaflet and supported attachment of human aortic valve cells. These results reveal that hybrid APS-co-PEG/PCL scaffolds may serve as promising constructs for soft tissue engineering, especially heart valve tissue engineering. Copyright (C) 2017 John Wiley & Sons, Ltd.
机译：具有可调节机械和物理化学性质的生物可降解合成弹性体仍然是软组织工程的诱人材料。我们最近合成了新型聚（1,3-二氨基-2-羟基丙烷-共癸二酸甘油酯）-共聚（乙二醇）（APS-co-PEG）可生物降解弹性体。与目前可用的可生物降解弹性体相比，这类聚乙二醇化弹性体具有广泛可调的机械和降解性能。为了进一步研究这类弹性体的生物应用，我们通过静电纺丝制备了APS-co-PEG/聚己内酯（PCL）复合多孔支架。对APS-co-PEG/PCL电纺复合支架的纤维形态、化学成分、力学性能、降解性和细胞相容性进行了表征。这些支架表现出广泛的机械性能，并与PCL支架具有相似的细胞相容性。重要的是，与PCL和APS/PCL支架相比，聚乙二醇化抑制了所有APS-co-PEG/PCL电纺支架上的血小板粘附，表明其在减轻体内血栓形成方面具有潜在作用。此外，APS-25PEG/PCL支架在机械上类似于人类心脏瓣膜小叶，并支持人类主动脉瓣细胞的附着。这些结果表明，APS-co-PEG/PCL复合支架有望成为软组织工程，尤其是心脏瓣膜组织工程的理想支架材料。版权所有（C）2017约翰威利父子有限公司。

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