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Role of platelets and megakaryocytes in adaptive immunity

机译：血小板和巨核细胞在适应症免疫中的作用

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摘要

The immune system is comprised of two principal interconnected components called innate and adaptive immunity. While the innate immune system mounts a nonspecific response that provides protection against the spread of foreign pathogens, the adaptive immune system has developed to specifically recognize a given pathogen and lead to immunological memory. Platelets are small fragments produced from megakaryocytes in bone marrow and lungs. They circulate throughout the blood to monitor the integrity of the vasculature and to prevent bleeding. Given their large repertoire of immune receptors and inflammatory molecules, platelets and megakaryocytes can contribute to both innate and adaptive immunity. In adaptive immunity, platelets and megakaryocytes can process and present antigens to lymphocytes. Moreover, platelets,viaFc gamma RIIA, rapidly respond to pathogens in an immune host when antibodies are present. This manuscript reviews the reported contributions of platelets and megakaryocytes with emphasis on antigen presentation and antibody response in adaptive immunity.
机译：免疫系统由两个相互关联的主要组成部分组成，称为先天免疫和适应性免疫。虽然先天性免疫系统会产生非特异性反应，为外来病原体的传播提供保护，但适应性免疫系统已经发展为专门识别特定病原体并导致免疫记忆。血小板是骨髓和肺中巨核细胞产生的小片段。它们在血液中循环，以监测血管系统的完整性并防止出血。鉴于血小板和巨核细胞拥有大量免疫受体和炎症分子，它们可以促进先天免疫和适应性免疫。在适应性免疫中，血小板和巨核细胞可以处理抗原并将其呈递给淋巴细胞。此外，当存在抗体时，血小板（viaFc gamma RIIA）对免疫宿主中的病原体迅速作出反应。本文综述了血小板和巨核细胞在适应性免疫中的作用，重点介绍了抗原提呈和抗体反应。

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