gilteritinib (xospata0) and acute leukaemia with a FLT3 gene mutation - An additional option for relapsed or refractory leukaemia

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gilteritinib (xospata0) and acute leukaemia with a FLT3 gene mutation - An additional option for relapsed or refractory leukaemia

机译：Gilteritinib（Xospata0）和急性白血病，具有FLT3基因突变 - 复发或难治性白血病的另外选择

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Acute myeloid leukaemia is a disease characterised by abnormal proliferation of cells of the myeloid lineage. It mainly affects adults over 65 years of age. In about one-third of cases, the tumour cells carry a FLT3 gene mutation, which is usually associated with a poor prognosis. The standard first-line treatment is a combination of several cytotoxic drugs: cytarabine with an anthracycline such as daunorubicinto induce remission, followed by so-called consolidation treatment to prevent relapse, with chemotherapy or haematopoietic stem cell transplantation. Stem cell transplantation is the option which offers the greatest chance of achieving prolonged remission.

机译：急性髓系白血病是一种以髓系细胞异常增殖为特征的疾病。它主要影响65岁以上的成年人。在大约三分之一的病例中，肿瘤细胞携带FLT3基因突变，这通常与不良预后有关。标准的一线治疗是几种细胞毒性药物的组合：阿糖胞苷和蒽环类药物（如柔红霉素）诱导病情缓解，然后进行所谓的巩固治疗，以防止复发，同时进行化疗或造血干细胞移植。干细胞移植是获得长期缓解的最大机会。

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《Prescrire international》 |2021年第226期|共1页
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1. Unilateral bullous retinal detachment in a child with acute lymphoblastic leukaemia,and hypopyon as the first sign of leukaemic relapse [J] . Sagili Chandrasekhara Reddy12 国际眼科杂志：英文版 . 2018,第010期
2. Fludarabine and cytarabine combined chemotherapy followed by transfusion of donor blood stem cells for treating relapse of acute leukaemia after allogeneic haematopoietic stem cell transplantation [J] . YOU Yong, LI Qiu-bai, CHEN Zhi-chao, 中华医学杂志（英文版） . 2008,第018期
3. Expression of partial tandem duplication of mixed lineage leukaemia in patients with acute leukaemia and their relatives [J] . He Yi, Wang Dongning, Li Xudong, 中华医学杂志（英文版） . 2014,第002期
4. Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study (vol 18, 1061, 2017) [J] . Perl A. E., Altman J. K., Cortes J. The lancet oncology . 2019,第6期

机译：在复发或难治性急性髓性白血病中通过Gilteritinib对FLT3的选择性抑制：多期，第一款，第一款，开放标签，第1-2期研究（第18卷，1061,2017）
5. Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study (vol 18, pg 1061, 2017) [J] . Perl A. E., Altman J. K., Cortes J. The lancet oncology . 2018,第7期

机译：在复发或难治性急性髓性白血病中，Gilteritinib的选择性抑制FLT3：多期，一年级，首先，开放标签，第1-2期研究（Vol 18，PG 1061,2017）
6. Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study [J] . Perl Alexander E., Altman Jessica K., Cortes Jorge, The lancet oncology . 2017,第8期

机译：在复发或难治性急性髓性白血病中，Gilteritinib的选择性抑制flt3：多期，第一型，首先，开放标签，第1-2期研究
7. Reliable classification of childhood acute leukaemia from gene expression data using confidence machines [C] . Bellotti T., Zhiyuan Luo, Gammerman A. Granular Computing, 2006 IEEE International Conference on . 2006

机译：使用信心机器从基因表达数据对儿童急性白血病进行可靠分类
8. Potential therapeutic options in treating leukemias bearing activating mutations of FLT3 and KIT. [D] . Canela, Victor Hugo. 2014

机译：在治疗带有FLT3和KIT激活突变的白血病中的潜在治疗选择。
9. The European Medicines Agency Review of Gilteritinib (Xospata) for the Treatment of Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with an FLT3 Mutation [O] . Kyriaki Tzogani, Hilde Røshol, Helga Haugom Olsen, 2020

机译：欧洲药物管理局对吉尔替尼（Xospata）的治疗其治疗具有FLT3突变的复发性或难治性急性髓性白血病成年患者
10. Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene [O] . Yasuyuki Nakano, Hitoshi Kiyoi, Shuichi Miyawaki, 1999

机译：复发中急性髓性白血病的分子演变：与P53基因相比，不稳定的N-RAS和FLT3基因
11. Acute Lymphocytic Leukaemia in Children in the Netherlands. Results of Treatment According to Protocol ALL II (Dutch Childhood Leukaemia Study Group) and Immunological Studies after Cessation of Therapy [R] . Does-van den Berg, A. 1980

机译：荷兰儿童急性淋巴细胞白血病。根据方案aLL II（荷兰儿童白血病研究组）和停止治疗后的免疫学研究的治疗结果

gilteritinib (xospata0) and acute leukaemia with a FLT3 gene mutation - An additional option for relapsed or refractory leukaemia

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