Gutllain-Barre syndrome, in brief

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Gutllain-Barre syndrome, in brief

机译：Guillain-Barre综合征，简要介绍

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Guillain-Barre syndrome is generally considered to be an autoimmune disease. It affects peripheral nerves. Many variants have been described. The most common variant is acute inflammatory demyelinating polyradiculoneuropathy, which accounts for about 85% to 90% of affected patients in Europe and the US (1). Its estimated annual incidence is 1 or 2 cases per 100 000 population, with no major geographic variation. This syndrome is more frequent in men, and its incidence increases with age (1). It is often preceded by a gastrointestinal or respiratory infection, such as Campylo-bacter jejuni or cytomegalovirus infection, or influenza (1-3). The first symptoms of Guillain-Barre syndrome are generally muscle weakness in the legs, more rarely in the arms or face, often accompanied by paraesthesia in the extremities (1). The muscle weakness spreads within several days or weeks. About half of patients have difficulty walking or become bed-ridden through paralysis. The facial muscles and the muscles required for swallowing are affected in half of patients. In 10% to 30% of cases, involvement of respiratory muscles requires ventilatory support (1).

机译：格林-巴利综合征通常被认为是一种自身免疫性疾病。它影响周围神经。已经描述了许多变体。最常见的变异是急性炎症性脱髓鞘性多神经根神经病，在欧洲和美国约占受影响患者的85%至90%（1）。其估计年发病率为每10万人口1或2例，无重大地理变异。该综合征在男性中更为常见，其发病率随年龄增长而增加（1）。感染前通常会出现胃肠道或呼吸道感染，如空肠弯曲菌或巨细胞病毒感染，或流感（1-3）。格林-巴利综合征的最初症状通常是腿部肌肉无力，很少出现在手臂或面部，通常伴有四肢感觉异常（1）。肌肉无力会在几天或几周内扩散。大约一半的患者行走困难或因瘫痪而卧床不起。半数患者的面部肌肉和吞咽所需的肌肉受到影响。在10%到30%的病例中，呼吸肌受累需要通气支持（1）。

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《Prescrire international》 |2016年第176期|共1页
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Gutllain-Barre syndrome, in brief

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