treosulfan (trecondi0) and preparation for haemopoietic stem cell transplantation

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treosulfan (trecondi0) and preparation for haemopoietic stem cell transplantation

机译：Treosulfan（Trecondi0）和血液化干细胞移植的制备

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A transplant of haemopoietic stem cells derived from a donor (i.e. an allogeneic transplant) is a potentially curative treatment for certain haemato-logical malignancies (leukaemias, myelodysplastic syndromes, lymphomas, multiple myeloma) and some non-malignant haematological diseases, including primary immunodeficiencies and haemo-globinopathies (1). Before receiving an allogeneic transplant, patients receive cytotoxic chemotherapy, possibly combined with radiotherapy.The objectives of this "conditioning" therapy are twofold: eradication of the disease for which the transplant is being given, and profound inhibition of the patient's immune system to prevent rejection of the transplanted cells. There is no consensus over which chemotherapy regimen to give.The combination of busulfan (an alkylating agent) + fludarabine (a nu-cleoside antimetabolite) is one of several options (2).

机译：来自供体的造血干细胞移植（即异基因移植）是某些血液系统恶性肿瘤（白血病、骨髓增生异常综合征、淋巴瘤、多发性骨髓瘤）和一些非恶性血液系统疾病（包括原发性免疫缺陷和血红蛋白病）的潜在治疗方法（1）。在接受同种异体移植之前，患者接受细胞毒性化疗，可能会结合放疗。这种“调理”疗法的目的有两个：根除移植所针对的疾病，以及深入抑制患者的免疫系统以防止移植细胞的排斥反应。对于采用哪种化疗方案，目前尚无共识。白消安（烷基化剂）+氟达拉宾（核苷抗代谢剂）的组合是几种选择之一（2）。

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《Prescrire international》 |2021年第224期|共2页
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1. Current status and development of hematopoietic stem cell transplantation in China： a report from Chinese Hematopoietic Stem Cell Transplantation Register Group [J] . XU Lan-ping, HUANG Xiao-jun 中华医学杂志：英文版 . 2011,第016期
2. Current status and development of hematopoietic stem cell transplantation in China: a report from Chinese Hematopoietic Stem Cell Transplantation Register Group [J] . XU Lan-ping, HUANG Xiao-jun 中华医学杂志（英文版） . 2011,第016期
3. Stem cell transplantation for treatment of cerebral ischemia in rats Effects of human umbilical cord blood stem cells and human neural stem cells [J] . Fenghua Pan, Xinsheng Ding, Haixia Ding, 中国神经再生研究（英文版） . 2010,第007期
4. Treosulfan-fludarabine-thiotepa conditioning before allogeneic haemopoietic stem cell transplantation for patients with advanced lympho-proliferative disease. A single centre study [J] . Baronciani Donatella, Depau Cristina, Targhetta Clara, Hematological oncology . 2016,第1期

机译：异基因造血干细胞移植前对患有晚期淋巴增生性疾病的患者进行硫磺-氟达拉滨-噻替普治疗。单中心研究
5. Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): a phase 3 biological assignment trial. [J] . Krishnan A, Pasquini MC, Logan B, The lancet oncology . 2011,第13期

机译：多发性骨髓瘤患者的自体造血干细胞移植，然后同种异体或自体造血干细胞移植（BMT CTN 0102）：3期生物学分配试验。
6. Risk assessment in adult acute lymphoblastic leukaemia before early haemopoietic stem cell transplantation with a geno-identical donor: an easy clinical prognostic score to identify patients who benefit most from allogeneic haemopoietic stem cell transplantation [J] . N-C Gorin, M Labopin, E Polge, Leukemia . 2003,第8期

机译：使用基因相同的供体在早期造血干细胞移植前进行成人急性淋巴细胞白血病的风险评估：一项简单的临床预后评分，可确定受益于同种异体造血干细胞移植的患者
7. Similarity and differences between the haemopoietic and brain stem cell system [C] . N. Uchida Society for Experimental Biology . 2001

机译：血化和脑干细胞系统之间的相似性和差异
8. Donor selection for patients undergoing allogeneic hematopoietic stem cell transplantation: Assessment of the priorities of Canadian hematopoietic stem cell transplant physicians. [D] . Tay, Jason. 2009

机译：接受同种异体造血干细胞移植的患者的供体选择：加拿大造血干细胞移植医生的优先事项评估。
9. Improved Clinical Outcomes of High Risk β Thalassemia Major Patients Undergoing a HLA Matched Related Allogeneic Stem Cell Transplant with a Treosulfan Based Conditioning Regimen and Peripheral Blood Stem Cell Grafts [O] . Vikram Mathews, Biju George, Auro Viswabandya, -1

机译：接受基于硫丹的条件疗法和外周血干细胞移植的HLA匹配相关同种异体干细胞移植的高危β地中海贫血重症患者的改善的临床结果
10. Risk assessment in adult acute lymphoblastic leukaemia before early haemopoietic stem cell transplantation with a geno-identical donor: an easy clinical prognostic score to identify patients who benefit most from allogeneic haemopoietic stem cell transplantation [O] . N-C Gorin, M Labopin, E Polge, 2003

机译：成人急性淋巴细胞白血病在早期血糖干细胞移植前的风险评估：一种易于临床预后评分，以确定来自同种异体血液干细胞移植的大多数患者
11. Vaccination with Dendritic Cell Myeloma Fusions in Conjunction with Stem Cell Transplantation and PD-1 Blockade. [R] . Avigan, D. 2014

机译：结合干细胞移植和pD-1阻断与树突状细胞骨髓瘤融合接种。

treosulfan (trecondi0) and preparation for haemopoietic stem cell transplantation

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