Carbamazepine: loss of so-called absolute pitch

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Carbamazepine: loss of so-called absolute pitch

机译：carbamazepine：失去所谓的绝对间距

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Carbamazepine causes altered sound perception. This effect represents a significant handicap for patients who are musicians. The Rennes Regional Pharmacovigilance Centre (CRPV) reported the case of a 22-year-old patient who was a musician with so-called absolute (or perfect) pitch, i.e. having the ability to recognise a musical note played in isolation, without a reference note (1). Since starting carbamazepine treatment for epilepsy, he noticed a one semitone lowering of pitch perception. Eleven years later, carbamazepine discontinuation was followed by disappearance of this adverse effect.

机译：卡马西平会引起声音感知的改变。这种效应代表了音乐家患者的一个重大障碍。雷恩地区药物警戒中心（CRPV）报告了一名22岁患者的病例，他是一名具有所谓绝对（或完美）音高的音乐家，即能够识别单独演奏的音符，而无需参考音符（1）。自从开始卡马西平治疗癫痫以来，他注意到音调知觉降低了一个半音。11年后，卡马西平停药后，这种不良反应消失。

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《Prescrire international》 |2020年第216期|共1页
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中图分类药学;
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Carbamazepine: loss of so-called absolute pitch

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