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首页> 外文期刊>Progress in retinal and eye research >Vitreous and Vision Degrading Myodesopsia
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Vitreous and Vision Degrading Myodesopsia

机译：玻璃体和视力降解肌瘤

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Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state, transparency, and physiologic function(s) within the eye. Myopia and aging alter collagen and hyaluronan association causing concurrent gel liquefaction and fibrous degeneration. The resulting vitreous opacities and collapse of the vitreous body during posterior vitreous detachment are the most common causes for the visual phenomenon of vitreous floaters. Previously considered innocuous, the vitreous opacities that cause floaters sometimes impact vision by profoundly degrading contrast sensitivity function and impairing quality-of-life. While many people adapt to vitreous floaters, clinically significant cases can be diagnosed with Vision Degrading Myodesopsia based upon echographic assessment of vitreous structure and by measuring contrast sensitivity function. Perhaps due to the ubiquity of floaters, the medical profession has to date largely ignored the plight of those with Vision Degrading Myodesopsia. Improved diagnostics will enable better disease staging and more accurate identification of severe cases that merit therapy. YAG laser treatments may occasionally be slightly effective, but vitrectomy is currently the definitive cure. Future developments will usher in more informative diagnostic approaches as well as safer and more effective therapeutic strategies. Improved laser treatments, new pharmacotherapies, and possibly non-invasive optical corrections are exciting new approaches to pursue. Ultimately, enhanced understanding of the underlying pathogenesis of Vision Degrading Myodesopsia should result in prevention, the ultimate goal of modern Medicine.
机译：大分子仅占玻璃体的2%，但对其凝胶状态、透明度和眼部生理功能负责。近视和衰老改变了胶原和透明质酸的相关性，导致凝胶液化和纤维变性。玻璃体后脱离时产生的玻璃体混浊和玻璃体塌陷是玻璃体漂浮物视觉现象的最常见原因。以前被认为是无害的，导致漂浮物的玻璃体混浊有时会严重降低对比敏感度功能，损害生活质量，从而影响视力。虽然许多人适应了玻璃体漂浮物，但临床上有意义的病例可以通过对玻璃体结构的超声评估和对比敏感度功能的测量，诊断为视力下降性肌病。也许是由于漂浮者的普遍存在，医学界迄今为止在很大程度上忽视了视力下降的肌病患者的困境。改进的诊断方法将有助于更好的疾病分期和更准确地识别值得治疗的严重病例。YAG激光治疗偶尔会有轻微的效果，但玻璃体切除术目前是最终的治疗方法。未来的发展将带来更多信息的诊断方法以及更安全、更有效的治疗策略。改进的激光治疗、新的药物治疗，以及可能的非侵入性光学矫正，都是令人兴奋的新方法。最终，加强对视力下降性肌病的潜在发病机制的理解应该导致预防，这是现代医学的最终目标。

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