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首页> 外文期刊>Analytical methods >Analysis of alkyl esters of p-hydroxybenzoic acid (parabens) in baby teethers via gas chromatography-quadrupole mass spectrometry (GC-qMS) using a stable isotope dilution assay (SIDA)
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Analysis of alkyl esters of p-hydroxybenzoic acid (parabens) in baby teethers via gas chromatography-quadrupole mass spectrometry (GC-qMS) using a stable isotope dilution assay (SIDA)

机译：使用稳定同位素稀释法（SIDA）通过气相色谱-四极杆质谱（GC-qMS）分析婴儿牙胶中对羟基苯甲酸（对羟基苯甲酸酯）的烷基酯

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摘要

Alkyl esters of rho-hydroxybenzoic acid (parabens) are well-known to be used as preservatives in pharmaceuticals, cosmetics, and food products due to their antimicrobial effect. However, parabens are also known to act as endocrine disruptors. Thus, if manufactures of consumer goods use parabens particularly in products for infants and young children, this application should be considered as critical and should be thoroughly investigated, at least if an intake into the body cannot be excluded. The present work describes an analytical method for the analysis of methyl-, ethyl- and n-propylparaben (MeP, EtP and n-PrP) in plastic and gel material from baby teethers filled with cooling gel. Measurements were performed with gas chromatography-quadrupole mass spectrometry (GC-qMS) on N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) derivatized parabens. Samples were prepared applying ultrasonic assisted extraction (UAE) using methanol as the solvent. For quantification, a stable isotope dilution assay (SIDA) was used that showed good recoveries for spiked gel material, which ranged from 82 to 119%. The baby teether analyses showed that parabens were present in all considered plastic and gel samples. Furthermore, in all gel samples (2E,4E)-hexa-2,4-dienoic acid (sorbic acid) was identified as an additional preservative.
机译：众所周知，由于羟基羟基苯甲酸的烷基酯（对羟基苯甲酸酯）具有抗微生物作用，因此被用作药物，化妆品和食品中的防腐剂。然而，对羟基苯甲酸酯也被称为内分泌干扰物。因此，如果消费品制造商尤其在婴幼儿产品中使用对羟基苯甲酸酯，则至少在不能排除摄入人体的情况下，应将此应用视为至关重要的，并应进行彻底研究。本工作描述了一种分析方法，该方法用于分析装有冷却凝胶的婴儿牙胶中的塑料和凝胶材料中的对羟基苯甲酸甲酯，对羟基苯甲酸乙酯和正丙基对羟基苯甲酸甲酯（MeP，EtP和n-PrP）。用N，O-双（三甲基甲硅烷基）三氟乙酰胺（BSTFA）衍生的对羟基苯甲酸酯用气相色谱-四极杆质谱（GC-qMS）进行测量。使用甲醇作为溶剂，通过超声辅助萃取（UAE）制备样品。为了进行定量分析，使用了稳定的同位素稀释测定法（SIDA），该方法对加标的凝胶材料的回收率良好，范围从82％到119％。婴儿牙胶的分析表明对羟基苯甲酸酯存在于所有考虑的塑料和凝胶样品中。此外，在所有凝胶样品中，（2E，4E）-六-2,4-二烯酸（山梨酸）被鉴定为其他防腐剂。

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