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首页> 外文期刊>Psychiatry Research. Neuroimaging >Alterations of Cerebral Blood Flow Network in Behavioral Variant Frontotemporal Dementia patients with and without Apathy
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Alterations of Cerebral Blood Flow Network in Behavioral Variant Frontotemporal Dementia patients with and without Apathy

机译：无冷漠的行为变体型颞型痴呆患者脑血流网络的改变

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摘要

Apathy is one of the core symptoms in behavioral variant of frontotemporal dementia (bvFTD), and increases patient's morbidity and caregiver's distress. In this study, we applied a graph theoretical analysis (GTA) to analyze the topological properties of cerebral blood flow (CBF) network in 64 bvFTD patients with and without apathy (47 bvFTD-apathy and 17 bvFTD-woapathy, respectively), and 20 normal controls (NCs) based on single photon emission tomography (SPECT). Compared with the NCs, both the bvFTD groups preserved global function and typical features of small-worldness, but exhibited the loss of hubs mainly distributed in the prefrontal cortex (PFC). Compared with bvFTD-woapathy, the bvFTD-apathy group exhibited additional loss of hubs in the ventral PFC areas, middle cingulate cortex, limbic and paralimbic system, and subcortical regions, but recruited hubs in the areas of angular gyrus, precuneus and posterior cingulate cortex. Overall, our findings support the hypothesis that the disruption of frontostriatal circuit is associated with apathy in bvFTD.
机译：冷漠是额颞叶痴呆（bvFTD）行为变异的核心症状之一，会增加患者的发病率和护理者的痛苦。在这项研究中，我们应用图论分析（GTA）对64例伴有和不伴有冷漠的bvFTD患者（分别为47例bvFTD和17例bvFTD）和20例正常对照者（NCs）基于单光子发射断层扫描（SPECT）的脑血流（CBF）网络拓扑特性进行了分析。与NCs组相比，bvFTD组均保留了整体功能和小世界的典型特征，但主要分布在前额叶皮质（PFC）的中枢缺失。与bvFTD-WOAPTHY相比，bvFTD-WOAPTHY组在腹侧PFC区、扣带回中皮质、边缘和边缘旁系统以及皮质下区域表现出额外的中枢缺失，但在角回、楔前叶和扣带回后皮质区域招募中枢。总的来说，我们的研究结果支持这样一个假设，即额叶纹状体回路的破坏与bvFTD患者的冷漠有关。

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