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首页> 外文期刊>Psychiatry Research. Neuroimaging >Attention training modulates resting-state neurophysiological abnormalities in posttraumatic stress disorder
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Attention training modulates resting-state neurophysiological abnormalities in posttraumatic stress disorder

机译：注意训练在创伤性应激障碍中调节休息状态的神经生理异常

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Abstract Recent research indicates the relative benefits of computerized attention control treatment (ACT) and attention bias modification treatment (ABMT) for posttraumatic stress disorder (PTSD); however, neural changes underlying these therapeutic effects remain unknown. This study examines how these two types of attention training modulate neurological dysfunction in veterans with PTSD. A community sample of 46 combat veterans with PTSD participated in a randomized double-blinded clinical trial of ACT versus ABMT and 32 of those veterans also agreed to undergo resting-state magnetoencephalography (MEG) recordings. Twenty-four veterans completed psychological and MEG assessments at pre- and post-training to evaluate treatment effects. MEG data were imaged using an advanced Bayesian reconstruction method and examined using statistical parametric mapping. In this report, we focus on the neural correlates and the differential treatment effects observed using MEG; the results of the full clinical trial have been described elsewhere. Our results indicated that ACT modulated occipital and ABMT modulated medial temporal activity more strongly than the comparative treatment. PTSD symptoms decreased significantly from pre- to post-test. These initial neurophysiological outcome data suggest that ACT modulates visual pathways, while ABMT modulates threat-processing regions, but that both are associated with normalizing aberrant neural activity in veterans with PTSD. Highlights ? PTSD is associated with neurophysiological aberrations across multiple networks. ? These activation differences can be partially reversed by attention training. ? Attention control training modulates visual pathways which are understudied in PTSD. ? Attention bias modification modulates threat-processing regions in PTSD.
机译：摘要最近的研究表明，计算机化注意控制治疗（ACT）和注意偏差矫正治疗（ABMT）对创伤后应激障碍（PTSD）有相对的益处；然而，这些治疗效果背后的神经变化仍然未知。本研究探讨了这两种注意力训练如何调节PTSD退伍军人的神经功能障碍。46名患有PTSD的退伍军人参加了ACT与ABMT的随机双盲临床试验，其中32名退伍军人也同意接受静息状态脑磁图（MEG）记录。24名退伍军人在训练前后完成了心理和MEG评估，以评估治疗效果。MEG数据使用先进的贝叶斯重建方法成像，并使用统计参数映射进行检查。在本报告中，我们着重于神经相关因素和使用MEG观察到的差异治疗效果；完整临床试验的结果已在其他地方描述。我们的结果表明，ACT对枕叶的调节和ABMT对内侧颞叶活动的调节比对照组更强。从测试前到测试后，PTSD症状显著减轻。这些最初的神经生理学结果数据表明，ACT调节视觉通路，而ABMT调节威胁处理区域，但两者都与PTSD退伍军人异常神经活动的正常化有关。亮点？PTSD与跨多个网络的神经生理学异常有关？注意力训练可以部分逆转这些激活差异？注意力控制训练可以调节PTSD中未被研究的视觉通路？注意偏差修正调节PTSD中的威胁处理区域。

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