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Cortical properties of adults with autism spectrum disorder and an IQ100

机译:自闭症谱系障碍和IQ&GT的成人皮质性质。100

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Previous studies on cortical volume and thickness measures in autism spectrum disorders (ASD) show inconsistent results. We acquired structural magnetic resonance images of 30 individuals with ASD and individually matched controls and extracted surface-based and deformation-based morphometry measures. All participants had an IQ>100. Neither surface-based cortical thickness nor deformation based gyrification measures differed significantly across groups. Significant decreases but no increases of the gyrification index and sulcus depth could only be observed in the ASD group before correcting for multiple comparisons. This finding suggests that possible cortical anomalies in ASD are either weak or, given the heterogeneity of findings in earlier studies, might only apply to small ASD-subgroups.
机译:先前关于自闭症谱系障碍(ASD)的皮质体积和厚度测量的研究表明结果不一致。我们获得了30名ASD患者和单独匹配的对照者的结构磁共振图像,并提取了基于表面和基于变形的形态测量方法。所有参与者的智商均>100。基于表面的皮质厚度和基于变形的旋转测量在各组之间均无显著差异。在校正多重比较之前,只有ASD组的旋转指数和沟深度显著降低,但没有增加。这一发现表明,ASD中可能存在的皮质异常要么较弱,要么考虑到早期研究中发现的异质性,可能只适用于小的ASD亚群。

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