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首页> 外文期刊>Psychiatry Research. Neuroimaging >High schizotypy traits are associated with reduced hippocampal resting state functional connectivity
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High schizotypy traits are associated with reduced hippocampal resting state functional connectivity

机译：高精度性状与降低的海马休息状态功能连接有关

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Altered hippocampal functioning is proposed to play a critical role in the development of schizophrenia-spectrum disorders. Previous resting state functional Magnetic Resonance Imaging (rs-fMRI) studies report disrupted hippocampal connectivity in patients with psychosis and in individuals with clinical high risk, yet hippocampal connectivity has not been investigated in people with high schizotypy traits. Here we used rs-fMRI to examine hippocampal connectivity in healthy people with low (LS, n = 23) and high levels (HS, n = 22) of schizotypal traits assessed using the Schizotypy Personality Questionnaire. Using a bilateral hippocampal seed region, we examined resting state functional connectivity (RSFC) between hippocampus and striatal, thalamic and prefrontal cortex regions of interest. Compared to LS, HS participants showed lower RSFC between hippocampus and striatum and between hippocampus and thalamus. Whilst the group effect of reduced hippocampal RSFC in striatal and thalamic regions was driven by total schizotypy scores, positive schizotypy subfactor scores were significantly positively correlated with hippocampus-caudate/thalamus RSFC. Group differences in RSFC were not observed between hippocampus and prefrontal cortex. These results demonstrate that subclinical schizotypal traits are associated with altered hippocampal connectivity in striatal and thalamic regions and provide further support that hippocampal dysconnectivity confers risk for schizophrenia spectrum disorders.
机译：海马功能的改变被认为在精神分裂症谱系障碍的发展中起着关键作用。先前的静息状态功能磁共振成像（rs-fMRI）研究报告精神病患者和临床高危人群的海马连接性受损，但高分裂症特征人群的海马连接性尚未研究。在这里，我们使用rs功能磁共振成像来检查健康人的海马连接性，这些健康人具有低水平（LS，n=23）和高水平（HS，n=22）的分裂型人格特征，并使用分裂型人格问卷进行评估。利用双侧海马种子区，我们检测了海马与纹状体、丘脑和前额叶皮质相关区域之间的静息状态功能连通性（RSFC）。与LS相比，HS参与者在海马和纹状体之间以及海马和丘脑之间的RSFC较低。虽然纹状体和丘脑区海马RSFC降低的群体效应是由精神分裂症总评分驱动的，但阳性的精神分裂症亚因子评分与海马尾状体/丘脑RSFC显著正相关。在海马和前额叶皮质之间未观察到RSFC的组间差异。这些结果表明，亚临床分裂型特征与纹状体和丘脑区海马连接性的改变有关，并进一步证明海马连接性障碍会增加精神分裂症谱系障碍的风险。

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