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首页> 外文期刊>Psychiatry Research. Neuroimaging >Cortical gray matter structure in boys with Klinefelter syndrome
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Cortical gray matter structure in boys with Klinefelter syndrome

机译：klinefelter综合症的男孩的皮质灰质结构

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Klinefelter syndrome (KS, 47,XXY) is a common sex chromosome aneuploidy in males that is associated with a wide range of cognitive, social and emotional characteristics. The neural bases of these symptoms, however, are unclear. Brain structure in 19 pre- or early-pubertal boys with KS (11.5 +/- 1.8 years) and 22 typically developing (control) boys (8.1 +/- 2.3 years) was examined using surface-based analyses of cortical gray matter volume, thickness and surface area. Boys in the KS group were treatment-naive with respect to testosterone replacement therapy. Reduced volume in the insula and dorsomedial prefrontal cortex was observed in the KS relative to the TD group, as well as increased volume in the parietal, occipital and motor regions. Further inspection of surfacebased metrics indicated that whereas KS-associated increases in volume were driven by differences in thickness, KS-associated reductions in volume were associated with decreases in surface area. Exploratory analyses additionally indicated several correlations between brain structure and behavior, providing initial support for a neural basis of cognitive and emotional symptoms of this condition. Taken together, these data add support for a neuroanatomical phenotype of KS and extend previous studies through clarifying the precise neuroanatomical structural characteristics of that give rise to volumetric alterations.
机译：Klinefelter综合征（KS，47，XXY）是男性常见的性染色体非整倍体，与广泛的认知、社会和情绪特征有关。然而，这些症状的神经基础尚不清楚。对19名青春期前或早期患有KS（11.5+/-1.8岁）的男孩和22名正常发育（对照）的男孩（8.1+/-2.3岁）的大脑结构进行了基于表面的皮质灰质体积、厚度和表面积分析。KS组的男孩在睾酮替代疗法方面缺乏治疗经验。与TD组相比，KS组的脑岛和背内侧前额叶皮质体积减小，顶叶、枕叶和运动区体积增大。对基于表面的度量的进一步检查表明，尽管KS相关的体积增加是由厚度差异驱动的，但KS相关的体积减少与表面积减少相关。探索性分析还表明了大脑结构和行为之间的一些相关性，为这种情况下认知和情绪症状的神经基础提供了初步支持。综上所述，这些数据为KS的神经解剖学表型提供了支持，并通过阐明导致体积改变的精确神经解剖学结构特征，扩展了之前的研究。

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