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首页> 外文期刊>Psychiatry Research. Neuroimaging >Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study
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Structural characteristics of the brain reward circuit regions in patients with bipolar I disorder: A voxel-based morphometric study

机译：双相I紊乱患者大脑奖励电路区域的结构特征：基于体文素的形态学研究

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Abstract Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group. The results of the reward circuitry ROI analysis revealed lower gray matter volumes in the left ventromedial prefrontal cortex (VMPFC), left dorsomedial prefrontal cortex (DMPFC), and left ventrolateral prefrontal cortex (VLPFC) in patients with BD-I compared to HC. Our results suggest that abnormalities in the brain reward-processing neural circuitry, especially those in the left VMPFC, left DMPFC, and left VLPFC, may play an important role in the pathophysiology of BD-I. Highlights ? The left prefrontal cortex volume reduction is observed in patients with BD-I. ? The left VMPFC, left DMPFC and left VLPFC are related to reward processing. ? Brain reward circuitry is associated with pathophysiology of bipolar I disorder.
机译：摘要双相I型障碍（BD-I）常被误诊，导致治疗不足、严重残疾和生活质量下降。最近的神经模型表明，双相情感障碍患者的奖赏回路受到影响。本研究的目的是确定BD-I患者大脑奖赏处理神经回路的结构异常。21名BD-I患者和21名健康对照（HC）参与了本研究。进行结构磁共振成像。基于感兴趣区域（ROI）体素的形态计量学分析用于评估BD-I患者组和对照组之间是否存在结构变化。回报电路ROI分析结果显示，与HC相比，BD-I患者的左腹内侧前额叶皮质（VMPFC）、左背内侧前额叶皮质（DMPFC）和左腹外侧前额叶皮质（VLPFC）的灰质体积更低。我们的研究结果表明，大脑奖赏处理神经回路的异常，尤其是左侧VMPFC、左侧DMPFC和左侧VLPFC的异常，可能在BD-I的病理生理学中起重要作用？BD-I患者左前额叶皮质体积减少？左VMPFC、左DMPFC和左VLPFC与奖励处理有关？脑奖励回路与双相I型障碍的病理生理学有关。

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