White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study

Seitz Johanna; Lyall Amanda E.; Kanayama Gen; Makris Nikos; Hudson James I.; Kubicki Marek; Pope Harrison G. Jr.; Kaufman Marc J.

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White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study

机译：长期合成雄激素类固醇用户的白质异常：试点研究

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Recent studies of long-term anabolic-androgenic steroid (AAS) users reported amygdala structural and functional connectivity abnormalities. We assessed white matter microstructure in the inferior-fronto-occipital fasciculus (IFOF), a major associative bundle of the amygdala network. Diffusion weighted images acquired from 9 male long-term AAS users and 8 matched controls aged 36-51 years old were processed using a standardized pipeline (Tract-Based Spatial Statistics). Group differences were examined using linear regression with adjustment for age and current testosterone level. Compared to nonusers, AAS users exhibited significantly higher fractional anisotropy (FA) in the IFOF. Users showed markedly greater FA than nonusers on the left IFOF but only a modest, nonsignificant difference on the right IFOF. Moreover, FA was positively associated with lifetime cumulative AAS dose. Our results suggest that long-term AAS use alters IFOF white matter organization and integrity, which in turn might affect amygdala-related processes such as reward system function. Accordingly, further studies are needed to replicate findings in larger subject groups to determine the functional significance of the FA abnormality.

机译：最近对长期合成代谢雄激素类固醇（AAS）使用者的研究报告了杏仁核的结构和功能连接异常。我们评估了额枕下束（IFOF）中的白质微结构，IFOF是杏仁核网络的主要联合束。从9名长期使用AAS的男性用户和8名年龄在36-51岁的匹配对照组获得的扩散加权图像使用标准化管道（基于区域的空间统计）进行处理。组间差异采用线性回归分析，并根据年龄和当前睾酮水平进行调整。与非使用者相比，AAS使用者在IFOF中表现出显著更高的分数各向异性（FA）。在左侧的IFOF中，使用者的FA明显高于非使用者，但在右侧的IFOF中，两者之间的差异不大。此外，FA与AAS的终生累积剂量呈正相关。我们的研究结果表明，长期使用AAS会改变白质组织和完整性的功能，这反过来可能会影响杏仁核相关的过程，如奖赏系统功能。因此，需要进一步的研究，在更大的受试者群体中复制研究结果，以确定FA异常的功能意义。

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来源
《Psychiatry Research. Neuroimaging》 |2017年第2017期|共5页
作者
Seitz Johanna; Lyall Amanda E.; Kanayama Gen; Makris Nikos; Hudson James I.; Kubicki Marek; Pope Harrison G. Jr.; Kaufman Marc J.;
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作者单位

Harvard Med Sch Brigham &

Womens Hosp Dept Psychiat Psychiat Neuroimaging Lab Boston MA USA;

Harvard Med Sch Brigham &

Womens Hosp Dept Psychiat Psychiat Neuroimaging Lab Boston MA USA;

McLean Hosp Biol Psychiat Lab 115 Mill St Belmont MA 02178 USA;

Harvard Med Sch Brigham &

Womens Hosp Dept Psychiat Psychiat Neuroimaging Lab Boston MA USA;

McLean Hosp Biol Psychiat Lab 115 Mill St Belmont MA 02178 USA;

Harvard Med Sch Brigham &

Womens Hosp Dept Psychiat Psychiat Neuroimaging Lab Boston MA USA;

McLean Hosp Biol Psychiat Lab 115 Mill St Belmont MA 02178 USA;

Harvard Med Sch Brigham &

Womens Hosp Dept Psychiat Psychiat Neuroimaging Lab Boston MA USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Diffusion tensor imaging (DTI); Anabolic-androgenic steroids (AAS); Inferior-fronto-occipital fasciculus (IFOF); Tract-based spatial statistics (TBSS);

机译：扩散张量成像（DTI）;合成雄激素类固醇（AAS）;劣质 - 前枕束（IFOF）;基于传道的空间统计（TBS）;

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White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study

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