首页> 外国专利> METHOD FOR REDUCING WHITE MATTER LESIONS, WHITE MATTER HYPERINTENSITIES (WMH), LEUKOARAIOSIS OR PERIVENTRICULAR WHITE MATTER DISEASE IN ELDERLY

METHOD FOR REDUCING WHITE MATTER LESIONS, WHITE MATTER HYPERINTENSITIES (WMH), LEUKOARAIOSIS OR PERIVENTRICULAR WHITE MATTER DISEASE IN ELDERLY

机译:减少老年人的白质病变,白质超敏性(WMH),白细胞增多症或室性白质病变的方法

摘要

METHOD FOR REDUCING WHITE MATTER LESIONS, WHITE MATTER HYPERINTENSITIES (WMH), LEUKOARAIOSIS OR PERIVENTRICULAR WHITE MATTER DISEASE IN ELDERLY 5 The invention pertains to the use of one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof in the manufacture of a composition for treating, preventing or reducing the risk of occurrence of white matter lesions, white matter hyperintensities (WMH), Leukoaraiosis or periventricular white matter disease in elderly not suffering from a neurodegenerative disorder, preferably non-demented 10 elderly and elderly not suffering from Alzheimer’s Disease. It was found that with the compositions according to the invention Nogo-A protein levels could be controlled, particularly suppressed or reduced. [No suitable figure] 15
机译:减少老年人中白斑,白血脂过高(WMH),白血球增多或室周白斑病的方法本发明涉及一种或多种尿苷和胞苷或其盐,磷酸盐,酰基衍生物或酯的用途。制备用于治疗,预防或减少未患有神经退行性疾病的老年人,最好是非痴呆症的老年人和未患有神经变性疾病的老年人的白质病,白质高信号(WMH),白细胞增多症或脑室周围白质病发生的风险的组合物患有阿尔茨海默氏病。发现使用本发明的组合物可以控制,特别是抑制或降低Nogo-A蛋白水平。 [没有合适的身材] 15

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