首页> 外国专利> METHOD FOR REDUCING WHITE MATTER LESIONS, WHITE MATTER HYPERINTENSITIES (WMH), LEUKOARAIOSIS OR PERIVENTRICULAR WHITE MATTER DISEASE IN ELDERLY

METHOD FOR REDUCING WHITE MATTER LESIONS, WHITE MATTER HYPERINTENSITIES (WMH), LEUKOARAIOSIS OR PERIVENTRICULAR WHITE MATTER DISEASE IN ELDERLY

机译：减少老年人的白质病变，白质超敏性（WMH），白细胞增多症或室性白质病变的方法

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摘要

The invention pertains to the use of one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof in the manufacture of a composition for treating, preventing or reducing the risk of occurrence of white matter lesions, white matter hyperintensities (WMH), Leukoaraiosis or periventricular white matter disease in elderly not suffering from a neurodegenerative disorder, preferably non-demented elderly and elderly not suffering from Alzheimer's Disease. It was found that with the compositions according to the invention Nogo-A protein levels could be controlled, particularly suppressed or reduced.

机译：本发明涉及尿苷和胞苷中的一种或多种，或其盐，磷酸盐，酰基衍生物或酯在制备用于治疗，预防或减少白质损害，白质高强度（患有神经退行性疾病的老年人，最好是非痴呆的老年人和未患有阿尔茨海默氏病的老年人。发现使用本发明的组合物可以控制，特别是抑制或降低Nogo-A蛋白水平。

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公开/公告号US2017157164A1

专利类型
公开/公告日2017-06-08

原文格式PDF
申请/专利权人 N.V. NUTRICIA;
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申请/专利号US201515115487
发明设计人 NICK VAN WIJK;ROBERT JOHAN JOSEPH HAGEMAN;MEHMET CANSEV;
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申请日2015-02-02
分类号A61K31/7068;A61K31/202;A61K31/4415;A61K31/714;A61K31/519;A61K31/355;A61K31/375;A61K33/04;A61K31/683;A61K31/7072;A61K31/14;
国家 US
入库时间 2022-08-21 13:48:07

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