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首页> 外文期刊>Psychiatry Research. Neuroimaging >A distinctive abnormality of diffusion tensor imaging parameters in the fornix of patients with bipolar II disorder
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A distinctive abnormality of diffusion tensor imaging parameters in the fornix of patients with bipolar II disorder

机译：双极II疾病血栓血栓穹窿扩散张量成像参数的独特异常

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Abstract Diffusion tensor imaging (DTI) studies have revealed a changed integrity in the white matter of bipolar disorder. However, only a few investigations have examined bipolar II disorder (BP-II). A cross-sectional study was conducted to compare thirty-eight patients with BP-II (mean age = 38.26 years, F/M = 19/19) with thirty-eight age- and gender-matched healthy controls (mean age = 34.45 years, F/M = 18/20). Tract Based Spatial Statistics (TBSS) analysis of the fractional anisotropy (FA) was done with age, gender and education years as covariates, then a complementary atlas-based region-of-interest (ROI) analysis including the axial diffusivity (AD) and radial diffusivity (RD) was conducted to obtain further information. The patients with BP-II showed a significant decrease in FA in the corpus callosum (commissure fibers), fornix (association fibers) and right anterior corona radiata (projection fibers) compared to the controls. Moreover, a significant increase in the RD was observed in all of the fibers of the BP-II patients, while the AD significantly increased only in the fornix of the patients. Thus, in addition to the abnormal integrity of the commissure and projection fibers, the present study suggested an involvement of the limbic association fibers in the pathophysiology of BP-II induced by a distinctive neuropathology. Highlights ? Bipolar II patients had a significantly changed diffusion tensor imaging measures. ? The corpus callosum and fornix showed a lower value of the fractional anisotropy. ? A higher in the radial diffusivity was also observed in the main bundles. ? The axial diffusivity (AD), however, significantly increased only in the fornix. ? The altered AD may indicate a distinctive neurophathology of the fornix.
机译：摘要弥散张量成像（DTI）研究显示双相情感障碍患者白质的完整性发生了改变。然而，只有少数研究调查了双相情感障碍（BP-II）。进行了一项横断面研究，将38例BP-II患者（平均年龄=38.26岁，F/M=19/19）与38例年龄和性别匹配的健康对照组（平均年龄=34.45岁，F/M=18/20）进行比较。以年龄、性别和受教育年限为协变量，对分数各向异性（FA）进行基于域的空间统计（TBSS）分析，然后进行基于图集的感兴趣区域（ROI）补充分析，包括轴向扩散率（AD）和径向扩散率（RD），以获得更多信息。与对照组相比，BP-II患者胼胝体（连合纤维）、穹窿（联合纤维）和右前辐射冠（投射纤维）的FA显著降低。此外，在BP-II患者的所有纤维中观察到RD显著增加，而AD仅在患者的穹窿中显著增加。因此，除了连合和投射纤维的异常完整性外，本研究还表明边缘联系纤维参与了一种独特的神经病理学诱导的BP-II的病理生理学。亮点？双相II患者的扩散张量成像测量值发生了显著变化？胼胝体和穹窿的各向异性分数较低？在主束中也观察到较高的径向扩散率？然而，轴向扩散率（AD）仅在穹窿显著增加？改变后的AD可能表明穹窿具有独特的神经形态。

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