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首页> 外文期刊>Psychiatry Research. Neuroimaging >Frontal and subcortical grey matter reductions in PTSD
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Frontal and subcortical grey matter reductions in PTSD

机译：PTSD的正面和灰度灰质减少

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Abstract Post-traumatic stress disorder (PTSD) is characterised by a range of debilitating psychological, physical and cognitive symptoms. PTSD has been associated with grey matter atrophy in limbic and frontal cortical brain regions. However, previous studies have reported heterogeneous findings, with grey matter changes observed beyond limbic/frontal areas. Seventy-five adults were recruited from the community, 25 diagnosed with PTSD along with 25 healthy and 25 trauma exposed age and gender matched controls. Participants underwent clinical assessment and magnetic resonance imaging. The data-analyses method Voxel Based Morphometry (VBM) was used to estimate cortical grey matter volumes. When compared to both healthy and trauma exposed controls, PTSD subjects demonstrated decreased grey matter volumes within subcortical brain regions—including the hippocampus and amygdala—along with reductions in the anterior cingulate cortex, frontal medial cortex, middle frontal gyrus, superior frontal gyrus, paracingulate gyrus, and precuneus cortex. Significant negative correlations were found between total CAPS lifetime clinical scores/sub-scores and GM volume of both the PTSD and TC groups. GM volumes of the left rACC and right amygdala showed a significant negative correlation within PTSD diagnosed subjects. Highlights ? Three group study including trauma exposed controls and healthy controls. ? PTSD associated reductions in hippocampus, amygdala, and anterior cingulate cortex. ? PTSD associated reductions in insula, putamen and precuneus cortex. ? Correlation analysis of CAPS scores and grey matter volumes. ? Correlation analysis of rACC and amygdala grey matter volumes.
机译：摘要创伤后应激障碍（PTSD）的特点是一系列令人衰弱的心理、生理和认知症状。创伤后应激障碍与边缘和额叶皮质脑区的灰质萎缩有关。然而，之前的研究报告了不同的发现，在边缘/额叶区域以外观察到灰质变化。从社区招募了75名成年人，其中25名被诊断为PTSD，25名健康人和25名暴露于创伤的年龄和性别匹配的对照组。参与者接受临床评估和磁共振成像。数据分析方法基于体素的形态计量学（VBM）用于估计皮质灰质体积。与健康对照组和创伤对照组相比，PTSD受试者的皮层下区域（包括海马和杏仁核）内的灰质体积减少，前扣带回、额叶内侧皮质、额叶中回、额叶上回、扣带回旁回和楔前皮质减少。PTSD组和TC组的CAPS终身临床总分/分项得分与GM体积之间均存在显著负相关。在PTSD诊断受试者中，左侧rACC和右侧杏仁核的GM体积显示出显著的负相关。亮点？三组研究，包括创伤暴露对照组和健康对照组？PTSD相关的海马、杏仁核和前扣带回皮质减少？PTSD相关的岛叶、壳核和楔前叶皮质减少？CAPS评分与灰质体积的相关性分析？rACC和杏仁核灰质体积的相关分析。

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