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首页> 外文期刊>Psychiatry Research. Neuroimaging >The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder
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The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder

机译：5-HTTLPR和BDNF VAL66MET多态性对重大抑郁症神经结构变化的影响

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The serotonin-transporter-linked polymorphic region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have been implicated in the pathophysiology of major depressive disorder (MDD).We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. Ninety-five patients with MDD and 65 healthy participants aged 20-65 years were recruited. The subjects were genotyped for the 5-HTTLPR and BDNF Val66Met polymorphisms and scanned with T1-weighted and diffusion tensor imaging. The gray matter volumes of 24 gyri in the prefrontal and anterior cingulate cortices and the fractional anisotropy values of nine white matter tracts in both hemispheres were determined. In the pooled sample of subjects from both groups, 5HTTLPR L-allele carriers had significantly decreased cortical volume in the right anterior midcingulate gyrus compared to S- allele homozygotes. A significant effect of the interaction of the BDNF Val66Met polymorphism and MDD on the fractional anisotropy values of the right uncinate fasciculus was observed. Our results suggested that these genetic polymorphisms play important roles in the neurostructural changes of emotion-processing regions in subjects with MDD.
机译：5-羟色胺转运体相关多态区（5-HTTLPR）和脑源性神经营养因子（BDNF）Val66Met多态性与重度抑郁症（MDD）的病理生理学有关。我们旨在研究5-HTTLPR和BDNF Val66Met多态性的遗传变异及其与MDD的相互作用对皮质体积和白质完整性的影响。招募95名MDD患者和65名年龄在20-65岁的健康参与者。对受试者进行5-HTTLPR和BDNF Val66Met多态性基因分型，并进行T1加权和扩散张量成像扫描。测定了前额叶和前扣带回皮质24个脑回的灰质体积，以及两半球9个白质束的各向异性分数。在两组受试者的汇总样本中，与S等位基因纯合子相比，5HTTLPR L等位基因携带者右扣带回前部皮质体积显著减少。观察到BDNF Val66Met多态性和MDD相互作用对右侧钩束各向异性分数的显著影响。我们的研究结果表明，这些基因多态性在MDD患者情绪处理区域的神经结构变化中起着重要作用。

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