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Longitudinal investigation of the parietal lobe anatomy in bipolar disorder and its association with general functioning

机译：双相情感障碍中凸叶解剖学的纵向调查及其与一般运作的关联

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The parietal lobe (PL) supports cognitive domains, including attention and memory, which are impaired in bipolar disorder (BD). Although cross-sectional voxel-based morphometry studies found reduced PL grey matter (GM) in BD, none has longitudinally focused on PL anatomy in BD, relating it to patients' functioning. Thirtyeight right-handed BD patients and 42 matched healthy subjects (HS) underwent a Magnetic Resonance Imaging (MRI) scan at baseline. Seventeen BD patients and 16 matched HS underwent a follow-up MRI. PL white matter (WM) and GM volumes were measured. The trajectory of parietal volumes over time and the possible relation with the global functioning were investigated in both BD patients and HS. At baseline, BD patients showed significant reduced PL WM and GM and different WM laterality compared with HS. Furthermore, smaller PL WM volumes predicted lower global functioning in BD, but not in HS. At follow-up, although BD patients reported reduced PL WM compared with HS, no different pattern of volume changes over time was detected between groups. This study suggests the involvement of the PL in the pathophysiology of BD. In particular, PL WM reductions seem to predict an impairment in general functioning in BD and might represent a marker of functional outcome.
机译：顶叶（PL）支持认知领域，包括双相情感障碍（BD）中受损的注意力和记忆。尽管基于体素的横截面形态计量学研究发现BD中的PL灰质（GM）减少，但没有一项纵向研究关注BD中的PL解剖，将其与患者的功能联系起来。38名右利手BD患者和42名匹配的健康受试者（HS）在基线检查时接受了磁共振成像（MRI）扫描。17名BD患者和16名匹配的HS患者接受了后续MRI检查。测量PL白质（WM）和GM体积。对BD患者和HS患者的顶叶体积随时间的变化轨迹以及与整体功能的可能关系进行了研究。在基线检查时，与HS相比，BD患者的PL-WM和GM显著降低，WM偏侧性也不同。此外，较小的PL-WM体积预示着BD的整体功能较低，但HS的整体功能不明显。在随访中，虽然BD患者报告与HS相比PL-WM降低，但两组之间没有发现随时间变化的不同容积模式。这项研究表明PL参与了BD的病理生理学。特别是，PL-WM的减少似乎可以预测BD的总体功能受损，并可能代表功能结果的标志。

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