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Parietal lobe and disorganisation syndrome in schizophrenia and psychotic bipolar disorder: A bimodal connectivity study

机译:精神分裂症和精神病患者双相情感的榫叶和紊乱综合征:双峰连接研究

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Given the emerging evidence in support of parietal brain stimulation to treat speech disorder in psychosis, we investigated structural and functional parietal dysconnectivity in schizophrenia (n = 34) and bipolar disorder with psychotic symptoms (n = 16). We found that both patient groups demonstrated reduced left parietal structural connectivity compared to healthy controls (n = 32). The three groups also differed significantly on the variability of left and right parietal dynamic functional connectivity. In patients with schizophrenia, parietal dysconnectivity predicted the severity of disorganisation symptoms. These findings suggest that dysconnectivity between the parietal lobe and the rest of the brain plays a key role in disorganisation symptoms of schizophrenia.
机译:鉴于支持顶叶脑刺激治疗精神病患者言语障碍的新证据,我们调查了精神分裂症(n=34)和伴有精神病症状的双相情感障碍(n=16)患者的顶叶结构和功能连接障碍。我们发现,与健康对照组(n=32)相比,两组患者的左顶叶结构连通性均降低。三组在左右顶叶动态功能连接的变异性上也存在显著差异。在精神分裂症患者中,顶叶连通性障碍可以预测紊乱症状的严重程度。这些发现表明,顶叶和大脑其他部分之间的连接不良在精神分裂症的紊乱症状中起着关键作用。

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