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首页> 外文期刊>Psychiatry Research. Neuroimaging >Gray matter alteration in heroin-dependent men: An atlas-based magnetic resonance imaging study
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Gray matter alteration in heroin-dependent men: An atlas-based magnetic resonance imaging study

机译：海洛因依赖性男性的灰质改变：基于地图集的磁共振成像研究

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摘要

Previous imaging studies on heroin addiction have reported brain morphological alterations. However, the effects of heroin exposure on gray matter volume varied among different studies due to different factors such as substitution treatment or mandatory abstinence. Meanwhile, the relationship between gray matter and heroin use history remains unknown. Thirty-three male heroin-dependent (HD) individuals who are not under any substitution treatment or mandatory abstinence and 40 male healthy controls (HC) were included in this structural magnetic resonance imaging study. With an atlas-based approach, gray matter structures up to individual functional area were delineated, and the differences in their volumes between the HD and HC groups were analyzed. In addition, the relationship between gray matter volume and duration of heroin use was explored. The HD group demonstrated significantly lower cortical volume mainly in the prefrontal cortex and mesolimbic dopaminergic regions across different parcellation levels, whereas several visual and somatosensory cortical regions in the HD group had greater volume relative to the HC group at a more detailed parcellation level. The duration of heroin use was negatively correlated with the gray matter volume of prefrontal cortex. These findings suggest that heroin addiction be related to gray matter alteration and might be related to damage/maladaption of the inhibitory control, reward, visual, and somatosensory functions of the brain, although cognitive correlates are warranted in future study. In addition, the atlas-based morphology analysis is a potential tool to help researchers search biomarkers of heroin addiction.
机译：之前关于海洛因成瘾的影像学研究报告了大脑形态的改变。然而，由于替代治疗或强制戒断等不同因素，不同研究中海洛因暴露对灰质体积的影响不同。与此同时，灰质与海洛因使用史之间的关系仍不清楚。这项结构磁共振成像研究包括33名未接受任何替代治疗或强制戒断的男性海洛因依赖者（HD）和40名男性健康对照者（HC）。采用基于图谱的方法，描绘了各个功能区的灰质结构，并分析了HD组和HC组之间灰质体积的差异。此外，还探讨了灰质体积与海洛因使用持续时间之间的关系。HD组的皮质体积显著降低，主要分布在前额叶皮质和中边缘多巴胺能区，分布在不同的分区水平上，而HD组的几个视觉和体感皮质区域在更详细的分区水平上比HC组的体积更大。海洛因使用时间与前额叶皮质灰质体积呈负相关。这些发现表明，海洛因成瘾可能与灰质改变有关，也可能与大脑的抑制控制、奖赏、视觉和体感功能的损害/适应不良有关，尽管认知相关因素在未来的研究中得到了证实。此外，基于图谱的形态学分析是帮助研究人员寻找海洛因成瘾生物标志物的潜在工具。

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  • 来源
    《Psychiatry Research. Neuroimaging》 |2020年第1期|共9页
  • 作者

    Shi Hong; Liang Zifei; Chen Jiajie; Li Wei; Zhu Jia; Li Yongbin; Ye Jianjun; Zhang Jiangyang; Xue Jiuhua; Liu Wei; Wang Fan; Wang Wei; Li Qiang; He Xiaohai;

  • 作者单位

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    NYU Dept Radiol 560 1St Ave New York NY 10016 USA;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    NYU Dept Radiol 560 1St Ave New York NY 10016 USA;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Fourth Mil Med Univ Tangdu Hosp Dept Radiol 569 Xinsi Rd Xian 710038 Shaanxi Peoples R China;

    Sichuan Univ Coll Elect &

    Informat Engn Chengdu 610065 Peoples R China;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Heroin addiction; Gray matter; Magnetic resonance imaging; Large deformation diffeomorphic metric mapping;

    机译：海洛因成瘾;灰质;磁共振成像;大变形散晶度量映射;

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