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首页> 外文期刊>Psychiatry Research. Neuroimaging >Deactivation of anterior cingulate cortex during virtual social interaction in obsessive-compulsive disorder
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Deactivation of anterior cingulate cortex during virtual social interaction in obsessive-compulsive disorder

机译：在强迫症的虚拟社会互动期间去激活前刺皮层

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Studies about social functioning in obsessive-compulsive disorder (OCD) are lacking, even though neuroimaging studies and metacognition evaluation results suggest abnormal neural responses during social interactions. This study examined neural responses of OCD patients during handshakes with a virtual avatar. Because of the nature of the handshaking task, we expected that OCD patients with predominantly contamination/washing symptoms (CON) would show different neural responses compared to healthy controls (HCs) and to disease-controlled (NCON) patients. Thirteen CON, 13 NCON, and 18 HC participants performed handshake tasks with clean or dirty virtual avatars while undergoing functional magnetic resonance imaging. During handshakes with a clean avatar, deactivation in the left anterior cingulate cortex was found in CON patients compared to NCON and HC subjects. This cortical deactivation also occurred with dirty-avatar handshakes, but the difference was significant only between the two OCD groups and HC patients. Deactivation in the left anterior cingulate cortex was correlated with both OCD symptom severity and social anxiety traits. This cortical deactivation in OCD, especially in CON patients, suggests that social dysfunction in OCD may be due to interactions between OCD symptoms and impairment in social cognition, including emotional processing.
机译：尽管神经影像学研究和元认知评估结果表明，在社交互动过程中，神经反应异常，但关于强迫症（OCD）社会功能的研究仍然缺乏。这项研究考察了强迫症患者与虚拟化身握手时的神经反应。由于握手任务的性质，我们预计，与健康对照组（HCs）和疾病控制组（NCO）患者相比，具有主要污染/洗涤症状（CON）的强迫症患者会表现出不同的神经反应。13名CON、13名NCON和18名HC参与者在接受功能性磁共振成像时，与干净或肮脏的虚拟化身进行握手任务。在与干净的化身握手时，与对照组和对照组相比，对照组患者的左前扣带回皮质失活。这种皮质失活也发生在肮脏的化身握手中，但仅在两个强迫症组和HC患者之间存在显著差异。左前扣带回皮质失活与强迫症症状严重程度和社交焦虑特征相关。强迫症患者（尤其是CON患者）的这种皮质失活表明，强迫症的社会功能障碍可能是由于强迫症症状与包括情绪处理在内的社会认知障碍之间的相互作用所致。

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