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首页> 外文期刊>The Journal of Comparative Neurology >Altered spontaneous activity and effective connectivity of the anterior cingulate cortex in obsessive-compulsive disorder
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Altered spontaneous activity and effective connectivity of the anterior cingulate cortex in obsessive-compulsive disorder

机译：改变的自发活性和前刺伤皮质的有效连通性在强迫症中

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Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric disorder whose neurobiological basis remains unclear. Magnetic resonance imaging (MRI) studies have reported functional and structural alterations of the anterior cingulate cortex (ACC) in OCD. In this study, we explored the functional activity of subregions of the ACC and effective connectivity (EC) between ACC subregions and the whole brain in OCD. We used a Granger causality analysis (GCA) to identify the direction of information flow and whether the impact of that flow was excitatory or inhibitory. We performed resting-state functional MRI in 31 patients with OCD and 36 healthy controls and analyzed the amplitude of low-frequency fluctuation (ALFF) and coefficient-based GCA. The left pregenual ACC (pACC) in patients with OCD showed decreased ALFF relative to controls. There was significantly decreased excitatory output from the left pACC to both right dorsal superior frontal gyrus (dSFG) and left precuneus in patients compared with controls. Patients also had decreased inhibitory input to left pACC from left ventral SFG and left thalamus and caudate relative to controls. Results were similar in drug-naive patients and those with prior but not current psychopharmacological treatment. In patients, path coefficients of GCA from left pACC to right dSFG showed significant negative correlations with obsession and anxiety ratings. Decreased spontaneous neural activity and altered EC of pACC with widely distributed cortical circuitry, and associations with clinical ratings highlight the importance of pACC functional alteration in OCD.
机译：强迫症（OCD）是一种致残性神经精神障碍，其神经生物学基础尚不清楚。磁共振成像（MRI）研究报告了强迫症患者前扣带回皮质（ACC）的功能和结构改变。在本研究中，我们探讨了强迫症患者ACC亚区的功能活动以及ACC亚区与全脑之间的有效连通性（EC）。我们使用格兰杰因果分析（GCA）来确定信息流的方向，以及信息流的影响是兴奋性的还是抑制性的。我们对31例强迫症患者和36名健康对照者进行静息状态功能MRI检查，并分析低频波动幅度（ALFF）和基于系数的GCA。与对照组相比，强迫症患者的左肾前ACC（pACC）显示ALFF降低。与对照组相比，患者从左pACC到右背额上回（dSFG）和左楔前叶的兴奋性输出显著减少。与对照组相比，患者的左腹侧SFG、左丘脑和尾状核对左pACC的抑制性输入也有所减少。未接受药物治疗的患者和之前接受过但目前未接受心理药理学治疗的患者的结果相似。在患者中，从左pACC到右dSFG的GCA路径系数与强迫和焦虑评分呈显著负相关。自发神经活动减少，皮质回路广泛分布的pACC EC改变，以及与临床评分的相关性，突出了pACC功能改变在强迫症中的重要性。

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