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首页> 外文期刊>Psychiatry Research. Neuroimaging >Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder
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Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder

机译：改变的前刺刺伤皮质对海马有效的连通性，以应对可卡因使用障碍的男性药物线索

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Abstract Drug-related attentional bias may have significant implications for the treatment of cocaine use disorder (CocUD). However, the neurobiology of attentional bias is not completely understood. This study employed dynamic causal modeling (DCM) to conduct an analysis of effective (directional) connectivity involved in drug-related attentional bias in treatment-seeking CocUD subjects. The DCM analysis was conducted based on functional magnetic resonance imaging (fMRI) data acquired from fifteen CocUD subjects while performing a cocaine-word Stroop task, during which blocks of Cocaine Words (CW) and Neutral Words (NW) alternated. There was no significant attentional bias at group level. Although no significant brain activation was found, the DCM analysis found that, relative to the NW, the CW caused a significant increase in the strength of the right (R) anterior cingulate cortex (ACC) to R hippocampus effective connectivity. Greater increase of this connectivity was associated with greater CW reaction time (relative to NW reaction time). The increased strength of R ACC to R hippocampus connectivity may reflect ACC activation of hippocampal memories related to drug use, which was triggered by the drug cues. This circuit could be a potential target for therapeutics in CocUD patients. No significant change was found in the other modeled connectivities. Highlights ? This study investigated attentional bias in cocaine use disorder. ? Dynamic causal modeling was used to assess underlying neural circuits. ? Drug cues caused increase in anterior cingulate cortex to hippocampus effective connectivity. ? Greater increase of this connectivity was associated with greater reaction time during drug cues. ? May reflect anterior cingulate cortex activation of hippocampal memories related to drug use.
机译：摘要与药物相关的注意偏差可能对可卡因使用障碍（CocUD）的治疗有重要意义。然而，注意偏向的神经生物学尚未完全了解。本研究采用动态因果模型（DCM）对寻求治疗的CocUD受试者药物相关注意偏向的有效（定向）连接性进行分析。DCM分析基于15名CocUD受试者在执行可卡因单词Stroop任务时获得的功能性磁共振成像（fMRI）数据进行，在此期间，可卡因单词块（CW）和中性单词块（NW）交替出现。在组水平上没有显著的注意偏向。虽然没有发现明显的大脑激活，但DCM分析发现，相对于NW，CW导致右侧（R）前扣带回皮质（ACC）与R海马的有效连接强度显著增加。这种连接性的增加与更大的CW反应时间（相对于NW反应时间）有关。R ACC与R海马连接强度的增加可能反映了与药物使用相关的海马记忆的ACC激活，这是由药物线索触发的。该回路可能成为CocUD患者治疗的潜在靶点。在其他模型的连接性中未发现显著变化。亮点？这项研究调查了可卡因使用障碍中的注意偏向？动态因果模型被用来评估潜在的神经回路？药物线索导致前扣带回皮质与海马的有效连接增加？这种连接性的增加与药物提示期间的反应时间延长有关？可能反映了前扣带回皮质对与药物使用有关的海马记忆的激活。

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