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首页> 外文学位 >The basolateral amygdala, rostral anterior cingulate cortex and hippocampus: Interactions and differential involvement in memory consolidation for distinct components of a task.
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The basolateral amygdala, rostral anterior cingulate cortex and hippocampus: Interactions and differential involvement in memory consolidation for distinct components of a task.

机译：基底外侧杏仁核，前额扣带回皮层和海马：相互作用和差异参与记忆巩固的任务的不同组成部分。

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摘要

The basolateral amygdala (BLA) is involved in memory consolidation for many emotionally arousing tasks, such as inhibitory avoidance (IA), contextual fear conditioning and spatial water maze. Extensive evidence indicates that the BLA modulates memory consolidation via interactions with other brain regions, including the hippocampus and cortical regions. The anterior cingulate cortex (ACC) is similarly involved in memory for aversive tasks and is directly connected with the BLA. Recent evidence suggests that the ACC is composed of two functionally distinct regions, of which the rostral ACC (rACC) may be selectively involved in memory for training that involves nociceptive stimulation. Conversely, the hippocampus appears to be specifically involved in learning about contextual cues. The experiments in the current dissertation investigated the involvement of two regions of ACC in IA memory consolidation as well as the interaction between the BLA and rACC. In addition, the present dissertation examined the relative contributions of the hippocampus, rACC and BLA in memory consolidation of the context and footshock components of IA training. Chapter 1 provides a brief background for the dissertation, and describes the role of BLA, rACC and hippocampus in memory. Chapter 2 presents the findings regarding the dissociation of the rACC and cACC, as well as the interaction between the rACC and BLA during IA memory consolidation. OXO infusions into the rACC, but not cACC, enhanced retention for IA training. Furthermore, lesions of either the BLA or rACC blocked the memory enhancing effect of drug infusions into the other region, indicating that the BLA and rACC interact during IA memory consolidation. Chapter 3 presents the findings regarding the differential involvement of the hippocampus, rACC and BLA in memory consolidation for the context and the footshock training of IA. OXO infusions into the hippocampus enhanced retention when given after context, but not footshock, training and OXO infusions into the rACC enhanced retention when given after footshock, but not context, training of IA. Moreover, infusions of OXO into the BLA enhanced retention when given after either context or footshock training of IA. Chapter 4 discusses the findings and addresses unanswered questions.
机译：基底外侧杏仁核（BLA）参与了许多情感激发任务的记忆巩固，例如抑制回避（IA），情境恐惧调节和空间水迷宫。大量证据表明，BLA通过与其他大脑区域（包括海马和皮质区域）的相互作用来调节记忆巩固。前扣带回皮层（ACC）同样参与厌恶性任务的记忆，并直接与BLA连接。最近的证据表明，ACC由两个功能上不同的区域组成，其中有眉毛的ACC（rACC）可能选择性参与涉及伤害性刺激的训练记忆。相反，海马似乎专门参与了上下文提示的学习。本文的实验研究了ACC的两个区域参与IA记忆整合以及BLA与rACC之间的相互作用。此外，本论文研究了海马，rACC和BLA在IA训练的背景和足部震颤记忆巩固方面的相对贡献。第1章为论文提供了简要的背景知识，并介绍了BLA，rACC和海马在记忆中的作用。第2章介绍了有关rACC和cACC的解离以及IA记忆整合过程中rACC和BLA之间相互作用的发现。 OXO注入rACC，但不注入cACC，可以增强IA培训的保留率。此外，BLA或rACC的损伤阻止了药物注入其他区域的记忆增强作用，表明在IA记忆巩固期间BLA和rACC相互作用。第3章介绍了有关IA的背景和足部电击训练中海马，rACC和BLA在记忆巩固中的差异参与的发现。在情境训练后给予海马OXO可以增强保持力，而在进行电击训练后却不能通过rACC注入海马，但是在情境训练之后则可以通过向OXA注入rACC增强保持力。此外，在IA的背景训练或足底冲击训练后给BLA注入OXO可以增强保留。第4章讨论了发现并解决了未解决的问题。

著录项

  • 作者

    Malin, Emily L.;

  • 作者单位

    University of California, Irvine.;

  • 授予单位 University of California, Irvine.;
  • 学科 Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 83 p.
  • 总页数 83
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;
  • 关键词

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