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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock
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Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshock

机译：海马，前扣带回皮层和基底外侧杏仁核的记忆受累情况不同

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摘要

Extensive evidence from contextual fear conditioning experiments suggests that the hippocampus is involved in processing memory for contextual information. Evidence also suggests that the rostral anterior cingulate cortex (rACC) may be selectively involved in memory for nociceptive stimulation. In contrast, many findings indicate that the basolateral amygdala (BLA) is more broadly involved in modulating the consolidation of different kinds of information. To investigate further the differential involvement of these brain regions in memory consolidation, the present experiments used a modified inhibitory avoidance training procedure that took place on 2 sequential days to separate context training from footshock training. Male Sprague-Dawley rats were implanted with unilateral cannulae aimed at the (ⅰ) hippocampus, (ⅱ) rACC, or (ⅲ) BLA, and given infusions of the muscarinic cholinergic agonist oxotremorine (OXO) immediately after either context training (day 1) or footshock training in that context (day 2). OXO enhanced retention when infused into the hippocampus after context, but not footshock, training. Conversely, OXO infusions enhanced memory when administered into the rACC immediately after footshock, but not context, training. Lastly, intra-BLA OXO infusions enhanced retention when administered after either context or footshock training. These findings are consistent with evidence that the hippocampus and rACC play selective roles in memory for specific components of training experiences. Additionally, they provide further evidence that the BLA is more liberally involved in modulating memory consolidation for various aspects of emotionally arousing experiences.
机译：来自上下文恐惧调节实验的大量证据表明，海马参与了上下文信息的记忆处理。证据还表明，鼻前扣带回皮质（rACC）可能选择性参与伤害性刺激的记忆。相反，许多发现表明，基底外侧杏仁核（BLA）更广泛地参与调节各种信息的整合。为了进一步研究这些大脑区域在记忆巩固中的差异参与，本实验使用了经过改进的抑制回避训练程序，该程序在连续2天中进行，以将情景训练与足底冲击训练分开。雄性Sprague-Dawley大鼠植入针对（ⅰ）海马，（ⅱ）rACC或（ⅲ）BLA的单侧套管，并在进行任何一种情境训练后立即注射毒蕈碱胆碱能激动剂oxotremorine（OXO）（第1天）或在这种情况下进行足触训练（第2天）。 OXO可以在锻炼后注入海马体，而不是在进行电击训练时增强保留。相反，在震颤后立即向rACC给药时，OXO输注增强了记忆，但没有情境训练。最后，BLA OXO内输注可在进行情境训练或足部冲击训练后进行，从而增强保留效果。这些发现与海马和rACC在记忆中对训练经历的特定组成部分起选择性作用的证据一致。此外，它们提供了进一步的证据，表明BLA在涉及情绪唤起体验的各个方面更自由地参与了对记忆巩固的调节。

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