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首页> 外文期刊>Psychoneuroendocrinology: An International Journal >Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis
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Allostatic load is associated with psychotic symptoms and decreases with antipsychotic treatment in patients with schizophrenia and first-episode psychosis

机译：樟子抑菌载荷与精神病症状有关，并随着精神分裂症和第一集精神病患者的抗精神病药治疗而降低

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Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation anti psychotics. AL, psychotic symptoms and psychosocial functioning were assessed in a longitudinal design in patients with SCZ (n = 28), FEP (n = 28), and healthy controls (n = 53) at baseline and 6 and 12 weeks after commencement of antipsychotic therapy. AL at baseline was higher in patients with SCZ and FEP relative to controls, but not different between patients with SCZ and FEP. Adjusting for age and smoking, we found that positive symptoms were positively correlated with AL and psychosocial functioning was negatively correlated with AL at trend level. Linear mixed model analysis demonstrated that AL decreased after treatment was commenced in patients with SCZ and FEP between the baseline assessment and the 6 and 12-week follow-up. AL was not predictive of treatment response or symptomatic remission. Our data provide evidence for cumulative physiological dysregulation in patients with SCZ and FEP that is linked to the experience of current positive psychotic symptoms. AL could be a useful tool to monitor biological signatures related to chronic stress and unhealthy behaviors in schizophrenia.
机译：目前精神分裂症的病理生理学模型表明，应激对该疾病的病因和发展轨迹有贡献。我们研究了非稳态负荷（AL）是否在精神分裂症（SCZ）和首发精神病（FEP）患者中升高，并与精神病症状、社会和职业功能相关。AL是一种反映慢性应激引起的神经内分泌、免疫和代谢失调的综合指数。此外，我们还评估了第二代抗精神病药物治疗后AL的时间动态。在基线检查时以及抗精神病药物治疗开始后6周和12周，采用纵向设计，对SCZ（n=28）、FEP（n=28）和健康对照组（n=53）患者的AL、精神病性症状和心理社会功能进行评估。与对照组相比，SCZ和FEP患者在基线检查时的AL较高，但SCZ和FEP患者之间没有差异。根据年龄和吸烟情况进行调整后，我们发现阳性症状与AL呈正相关，心理社会功能与AL呈负相关。线性混合模型分析表明，在基线评估和6周及12周随访期间，SCZ和FEP患者开始治疗后，AL降低。AL不能预测治疗反应或症状缓解。我们的数据为SCZ和FEP患者的累积性生理失调提供了证据，这与当前积极的精神病症状有关。AL可能是监测与精神分裂症患者慢性应激和不健康行为相关的生物学特征的有用工具。

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