KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer

Sekino Yohei; Oue Naohide; Shigematsu Yoshinori; Ishikawa Akira; Sakamoto Naoya; Sentani Kazuhiro; Teishima Jun; Matsubara Akio; Yasui Wataru

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KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer

机译：KIFC1诱导对多西紫杉醇的抗性，与前列腺癌患者的存活有关

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Objectives: Prostate cancer (PCa) is a common malignancy worldwide. Docetaxel has been an important treatment option for patients with metastatic castration-resistant prostate cancer (CRPC). However, nearly all patients with CRPC treated with docetaxel eventually become refractory. In the present study, we analyzed the expression and distribution of kinesin family member Cl (KIFC1) in human PCa by immunohistochemistry and examined the effect of inhibiting KIFC1 expression on docetaxel resistance.

机译：目的：前列腺癌（PCa）是世界范围内常见的恶性肿瘤。多西紫杉醇一直是转移性去势抵抗前列腺癌（CRPC）患者的重要治疗选择。然而，几乎所有接受多西紫杉醇治疗的CRPC患者最终都变得难治。在本研究中，我们通过免疫组织化学分析了驱动蛋白家族成员Cl（KIFC1）在人类PCa中的表达和分布，并研究了抑制KIFC1表达对多西他赛耐药性的影响。

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来源
《Urologic oncology》 |2017年第1期|共1页
作者
Sekino Yohei; Oue Naohide; Shigematsu Yoshinori; Ishikawa Akira; Sakamoto Naoya; Sentani Kazuhiro; Teishima Jun; Matsubara Akio; Yasui Wataru;
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作者单位

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Urol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Urol Hiroshima Japan;

Hiroshima Univ Inst Biomed &

Hlth Sci Dept Mol Pathol Hiroshima Japan;

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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Prostate cancer; KIFC1; Cancer stem cells; Docetaxel;

机译：前列腺癌;KIFC1;癌症干细胞;多西紫杉醇;

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专利

1. Prostate-specific antigen half-life： a new predictor of progression- free survival and overall survival in Chinese prostate cancer patients [J] . Guo-Wen Lin, Xu-Dong Yao, Shi-Lin Zhang, 亚洲男性学杂志：英文版 . 2009,第004期
2. Prostate-specific antigen half-life: a new predictor of progression-free survival and overall survival in Chinese prostate cancer patients [J] . Guo-Wen Lin, Guo-Hai Shi, Xiao-Jian Qin, 亚洲男性学杂志（英文版） . 2009,第004期
3. Clinical activity of abiraterone plus prednisone in docetaxel-na(i)ve and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer [J] . Guo-Wen Lin, Gao-Xiang Li, Bo Dai, 亚洲男性学杂志（英文版） . 2019,第002期
4. Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells [J] . Guo-hai SHI, Wen-jun XIAO, Chun-guang MA, 中国药理学报：英文版 . 2010,第007期
5. KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer [J] . Sekino Yohei, Oue Naohide, Shigematsu Yoshinori, Urologic oncology . 2017,第1期

机译：KIFC1诱导对多西紫杉醇的抗性，与前列腺癌患者的存活有关
6. Re: The Effect of Metformin Use during Docetaxel Chemotherapy on Prostate Cancer Specific and Overall Survival of Diabetic Patients with Castration Resistant Prostate Cancer Reply [J] . The Journal of Urology . 2018,第5期

机译：Re：二甲双胍在多西红柿化疗过程中使用的疗法癌症癌前列腺癌特异性和整体存活率抗议前列腺癌癌症答复
7. Re: The Effect of Metformin Use during Docetaxel Chemotherapy on Prostate Cancer Specific and Overall Survival of Diabetic Patients with Castration Resistant Prostate Cancer [J] . Ozgur Berat Cem The Journal of Urology . 2018,第5期

机译：Re：二甲双胍在多西红柿化疗过程中使用的疗效抗癌前列腺癌前列腺癌特异性和整体存活
8. On Predicting Survival Opportunities for Prostate Cancer by COX Regression in PSU Patients Data [C] . Nattawut Thongpim, Chidchanok Choksuchat, Tanan Bejrananda, International Conference on Electrical Engineering/Electronics, Computer, Telecommunications and Information Technology . 2020

机译：通过PSU患者数据中的COX回归预测前列腺癌的生存机会
9. Mechanism of Extracellular Matrix Induced Tumor Survival and Drug Resistance in Castration-Resistant Prostate Cancer [D] . Chaudhary, Pooja. 2019

机译：细胞外基质诱导肿瘤存活和抗阉割前列腺癌的耐药机制
10. KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer [O] . Yohei Sekino, Naohide Oue, Yuki Koike, 2019

机译：KIFC1抑制剂CW069诱导前列腺癌细胞凋亡并逆转对多西他赛的耐药性
11. Increased ABCC4 Expression Induced by ERRα Leads to Docetaxel Resistance via Efflux of Docetaxel in Prostate Cancer [O] . Houbao Huang, Jing Li, Jing Shen, 2020

机译：由于前列腺癌在前列腺癌中，ERRα诱导的ABCC4表达增加导致多西紫杉醇的抗病抗性
12. Exploring a Novel Mechanism of Docetaxel Resistance in Prostate Cancer. [R] . Singh, A. 2014

机译：探索前列腺癌多西紫杉醇耐药的新机制。

KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer

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