Molecular complexity of taxane-induced cytotoxicity in prostate cancer cells

Mang Josef; Merkle Konstanze; Heller Martina; Schueler Julia; Tolstov Yanis; Li Jielin; Hohenfellner Markus; Duensing Stefan

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Molecular complexity of taxane-induced cytotoxicity in prostate cancer cells

机译：前列腺癌细胞中紫杉烷诱导的细胞毒性的分子复杂性

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Background: Taxanes are routinely used to treat men with advanced prostate cancer, yet their molecular mode of action is poorly characterized. Taxanes stabilize microtubules and may hence interfere with a plethora of cellular processes, most notably mitosis. However, prostate cancer is typically a slowly growing tumor suggesting that additional processes play a role in the response to taxanes.

机译：背景：紫杉烷是治疗晚期前列腺癌的常规药物，但其分子作用模式尚不明确。紫杉烷稳定微管，因此可能干扰过多的细胞过程，最显著的是有丝分裂。然而，前列腺癌通常是一种生长缓慢的肿瘤，这表明额外的过程在对紫杉烷的反应中发挥作用。

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来源
《Urologic oncology》 |2017年第1期|共1页
作者
Mang Josef; Merkle Konstanze; Heller Martina; Schueler Julia; Tolstov Yanis; Li Jielin; Hohenfellner Markus; Duensing Stefan;
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作者单位

Heidelberg Univ Sch Med Dept Urol Sect Mol Urooncol Heidelberg Germany;

Heidelberg Univ Sch Med Dept Urol Sect Mol Urooncol Heidelberg Germany;

Heidelberg Univ Sch Med Dept Urol Sect Mol Urooncol Heidelberg Germany;

Oncotest GmbH Heidelberg Germany;

Heidelberg Univ Sch Med Dept Urol Sect Mol Urooncol Heidelberg Germany;

Heidelberg Univ Sch Med Dept Urol Sect Mol Urooncol Heidelberg Germany;

Heidelberg Univ Sch Med Dept Urol Heidelberg Germany;

Heidelberg Univ Sch Med Dept Urol Sect Mol Urooncol Heidelberg Germany;

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原文格式 PDF
正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Prostate cancer; Docetaxel; ERK1/2;

机译：前列腺癌;多西紫杉醇;ERK1 / 2;

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3. The complexities of identifying a cell of origin for human prostate cancer [J] . Gail P Risbridger, Renea A Taylor 亚洲男性学杂志（英文版） . 2011,第001期
4. Effects of bortezomib in sensitizing human prostate cancer cell lines to NK-mediated cytotoxicity [J] . Wei Hu, Rui-Rui Zheng, Hui-Xia Cui, 亚洲男性学杂志（英文版） . 2012,第005期
5. Molecular complexity of taxane-induced cytotoxicity in prostate cancer cells [J] . Mang Josef, Merkle Konstanze, Heller Martina, Urologic oncology . 2017,第1期

机译：前列腺癌细胞中紫杉烷诱导的细胞毒性的分子复杂性
6. Generation of Potent Cytotoxic T Lymphocytes Against Castration-Resistant Prostate Cancer Cells by Dendritic Cells Loaded With Dying Allogeneic Prostate Cancer Cells [J] . HwangE.C., LimM.S., ImC.M., Scandinavian journal of immunology. . 2013,第2期

机译：负载垂死的同种异体前列腺癌细胞的树突状细胞生成抗去势抵抗性前列腺癌细胞的有效细胞毒性T淋巴细胞。
7. A novel pregnene analogs: synthesis, cytotoxicity on prostate cancer of PC-3 and LNCPa-AI cells and in silico molecular docking study [J] . Abdul-Rida Nabeel A., Farhan Ali M., Al-Masoudi Najim A., Molecular diversity . 2021,第2期

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8. Prostate Cancer-Specific mAb 5D4 Significantly Enhances the Cytotoxicity of Doxorubicin-Loaded Liposomes Against Target Cells In Vitro [C] . Rishikesh M. Sawant, Michael B. Cohen, Vladimir P. Torchilin, Controlled Release Society Annual Meeting and Exposition . 2007

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9. Cytotoxic Activity of Verbenaceae (Daniellia oliveri) & Solanaceae (Capsicum frutescens) on Breast Cancer, Prostate Cancer, and Colon Cancer cells. [D] . Howard, Kareem Sharif. 2011

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10. Taxane-Induced Blockade to Nuclear Accumulation of the Androgen Receptor Predicts Clinical Responses in Metastatic Prostate Cancer [O] . Medha S. Darshan, Matthew S. Loftus, Maria Thadani-Mulero, -1

机译：紫杉烷诱导阻断的雄激素受体的核积累预测转移性前列腺癌的临床反应
11. Generation of Potent Cytotoxic T Lymphocytes Against Castration-Resistant Prostate Cancer Cells by Dendritic Cells Loaded With Dying Allogeneic Prostate Cancer Cells [O] . E. C. Hwang, M.-S. Lim, C.-M. Im, 2013

机译：用垂死的同种异体前列腺癌细胞的树突细胞产生抗阉割抗阉割前列腺癌细胞的有效细胞毒性T淋巴细胞
12. Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core [R] . Ross, R. R. , Reichardt, J. , Coetzee, G. A. , 2002

机译：跨越种族的前列腺癌进展的分子决定因素。项目a - 人类5RD5a2基因和前列腺癌进展。项目B - 雄激素受体（aR）在前列腺癌进展中的信号传导。项目C - 前列腺癌进展核心的细胞和分子标记 - 流行病学核心

Molecular complexity of taxane-induced cytotoxicity in prostate cancer cells

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