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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Association of Fecal Markers of Environmental Enteric Dysfunction with Zinc and Iron Status among Children at First Two Years of Life in Bangladesh
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Association of Fecal Markers of Environmental Enteric Dysfunction with Zinc and Iron Status among Children at First Two Years of Life in Bangladesh

机译：孟加拉国前两年生命中锌和铁状况锌和锌和钢铁地位粪便标志

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摘要

Environmental enteric dysfunction (EED) causes gut inflammation and increased intestinal permeability leading to deficiencies in micronutrients such as zinc and iron. Fecal markers such as myeloperoxidase (MPO), neopterin (NEO), and alpha-1-anti-trypsin (AAT) can predict EED. The aim of this study was to examine the association between fecal markers of EED with zinc and iron status among children at first 2 years of life. Malnutrition and Enteric Disease Study Bangladeshi birth cohort data were used to conduct this analysis. Multivariable analyses using generalized estimating equations were performed to test the association between individual fecal markers with zinc or iron status of the children. A total of 265 children were enrolled in the study (male: female = 1: 1). Of the 627 stool samples collected (N = 222 children), 535, 511, and 577 were accompanied by zinc, ferritin, and soluble transferrin receptor values, respectively. Median (interquartile range [IQR]) values of AAT, MPO, and NEO were 0.33 (0.18-0.62) mg/g, 3,895.42 (1,563.76-8,432.82) ng/mL, and 890.81 (331.57-2,089.04) nmol/L, respectively. Overall, 60%, 71%, and 97% of samples were above the values considered normal in nontropical settings for AAT, MPO, and NEO, respectively. High AAT levels were significantly associated with low ferritin values after adjusting for age and gender (coefficient = -5.85; 95% confidence interval = -11.23 to -0.47; P value = 0.03). No such association was found between AAT and plasma zinc status. Myeloperoxidase and NEO were not associated with plasma zinc or iron status. The study results imply the importance of enteric protein loss in contributing to reduced ferritin levels at first 2 years of life.
机译：环境肠道功能障碍（EED）导致肠道炎症和肠道通透性增加，导致锌和铁等微量营养素缺乏。粪便标记物如髓过氧化物酶（MPO）、新喋呤（NEO）和α-1-抗胰蛋白酶（AAT）可以预测EED。本研究的目的是在儿童出生后的头2年中，研究EED粪便标志物与锌和铁状态之间的关系。营养不良和肠道疾病研究孟加拉国出生队列数据用于进行该分析。使用广义估计方程进行多变量分析，以测试单个粪便标记物与儿童锌或铁状态之间的关联。共有265名儿童参加了这项研究（男：女=1:1）。在收集的627份粪便样本中（N=222名儿童），535份、511份和577份分别伴有锌、铁蛋白和可溶性转铁蛋白受体值。AAT、MPO和NEO的中值（四分位间距[IQR]）分别为0.33（0.18-0.62）mg/g、3895.42（1563.76-8432.82）ng/mL和890.81（331.57-2089.04）nmol/L。总的来说，60%、71%和97%的样本分别高于AAT、MPO和NEO在非热带环境下的正常值。调整年龄和性别后，高AAT水平与低铁蛋白值显著相关（系数=-5.85；95%置信区间=-11.23至-0.47；P值=0.03）。AAT与血浆锌水平之间未发现这种关联。髓过氧化物酶和NEO与血浆锌或铁状态无关。研究结果表明，在出生后的头2年，肠道蛋白质的丢失对铁蛋白水平的降低起到了重要作用。

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