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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Trypanosoma cruzi Infection Does Not Decrease Survival or Reproduction of the Common Bed Bug, Cimex lectularius
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Trypanosoma cruzi Infection Does Not Decrease Survival or Reproduction of the Common Bed Bug, Cimex lectularius

机译：曲盼瘤Cruzi感染不会降低常见床虫的存活或繁殖，Cimex Lectularius

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摘要

Although not presently implicated as a vector of human pathogens, the common bed bug, Cimex lectularius, has been suspected of carrying human pathogens because of its close association with humans and its obligate hematophagy. Recently, we characterized the vectorial competence of C. lectularius for the parasite Trypanosoma cruzi, the causative agent of Chagas disease. We observed that C. lectularius can acquire T. cruzi infection when fed on T. cruzi-carrying mice, and subsequently transmit T. cruzi to uninfected mice. This led us to ask why has C. lectularius not been implicated in the transmission of T. cruzi outside of the laboratory? We hypothesized that T. cruzi reduces C. lectularius fitness (i.e., survival and/or reproduction) as an explanation for why C. lectularius does not to transmit T. cruzi in natural settings. We tested this hypothesis by comparing the survival and reproduction of uninfected and T. cruzi-infected C. lectularius. We observed that T. cruzi had a variable effect on C. lectularius survival and reproduction. There were negligible differences between treatments in juveniles. Infected adult females tended to live longer and produce more eggs. However, no effect was consistent, and infected bugs showed more variation in survival and reproduction metrics than control bugs. We did not observe any negative effects of T. cruzi infection on C. lectularius survival or reproduction, suggesting that decreased fitness in T. cruzi-infected C. lectularius is not why bed bugs have not been observed to transmit T. cruzi in natural settings.
机译：虽然目前尚未被认为是人类病原体的载体，但由于其与人类的密切联系及其专性噬血作用，常见的臭虫Cimex LECTULIAUS已被怀疑携带人类病原体。最近，我们描述了选择梭菌对寄生虫克鲁兹锥虫的媒介能力，克鲁兹锥虫是恰加斯病的病原体。我们观察到，当喂食携带T.cruzi的小鼠时，隐孢子虫可以感染T.cruzi，然后将T.cruzi传播给未感染的小鼠。这让我们不禁要问，为什么克氏锥虫与克氏锥虫在实验室外的传播无关？我们假设T.cruzi降低了隐孢子虫的适应度（即生存和/或繁殖），以此解释隐孢子虫为什么不在自然环境中传播T.cruzi。我们通过比较未感染和克鲁兹锥虫感染的隐孢子虫的存活和繁殖来验证这一假设。我们观察到克氏锥虫对毛锥虫的存活和繁殖有不同的影响。在青少年中，两种治疗方法之间的差异可以忽略不计。受感染的成年雌性往往寿命更长，产卵更多。然而，没有一种效果是一致的，受感染的细菌在存活和繁殖指标上比对照细菌表现出更多的差异。我们没有观察到克氏锥虫感染对毛壳锥虫存活或繁殖的任何负面影响，这表明感染克氏锥虫的毛壳锥虫的适应度降低并不是没有观察到臭虫在自然环境中传播克氏锥虫的原因。

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