Case Report: Prolonged Viral Shedding in Six COVID-19 Patients

Alsaud Arwa E.; Nair Arun Prabhakaran; Matarneh Ahmad S.; Sasi Sreethish; El Hassan Rania; Khan Fahmi; Coyle Peter; Abu Khattab Mohamed; Mohamed Mouhand F. H.

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Case Report: Prolonged Viral Shedding in Six COVID-19 Patients

机译：案例报告：六个Covid-19患者的延长病毒脱落

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COVID-19 has surfaced as a multi-organ disease predominantly affecting the respiratory system. Detection of the viral RNA through reverse transcriptase-PCR (RT-PCR) from a nasopharyngeal or throat sample is the preferred method of diagnosis. Recent evidence has suggested that COVID-19 patients can shed the SARS-CoV-2 for several weeks. Herein, we report six cases of COVID-19 who had persistently positive SARS-CoV-2 on repeat RT-PCR testing reaching up to 9 weeks. The spectrum of cases described ranges from asymptomatic infection to severe COVID-19 pneumonia. A full understanding of the virus's transmission dynamics needs further research. Prolonged viral shedding currently has unclear implications on the management and isolation decisions-the role of the cycle threshold (Ct) value in guiding therapeutic decisions is yet to be clarified. More data on the relationship between Ct values and viral cultivation are needed, especially in patients with prolonged viral shedding, to understand the virus's viability and infectivity.

机译：2019冠状病毒疾病作为一种多器官疾病，主要影响呼吸系统。通过逆转录酶PCR（RT-PCR）从鼻咽或咽喉样本中检测病毒RNA是首选的诊断方法。最近的证据表明2019冠状病毒疾病患者可以释放SARS COV-2。在此，我们报告2019冠状病毒疾病患者六例，持续性RSA-PCR检测阳性率达9周。所描述的病例范围从无症状感染到严重COVID-19肺炎。全面了解病毒的传播动态需要进一步研究。目前，病毒持续脱落对治疗和隔离决定的影响尚不清楚。循环阈值（Ct）在指导治疗决定中的作用尚待阐明。需要更多关于Ct值与病毒培养之间关系的数据，尤其是对于病毒脱落时间较长的患者，以了解病毒的生存能力和传染性。

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《The American Journal of Tropical Medicine and Hygiene》 |2021年第4期|共4页
作者
Alsaud Arwa E.; Nair Arun Prabhakaran; Matarneh Ahmad S.; Sasi Sreethish; El Hassan Rania; Khan Fahmi; Coyle Peter; Abu Khattab Mohamed; Mohamed Mouhand F. H.;
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Hamad Med Corp Hamad Gen Hosp Dept Med Doha Qatar;

Hamad Med Corp Communicable Dis Ctr Dept Infect Dis Doha Qatar;

Hamad Med Corp Hamad Gen Hosp Dept Med Doha Qatar;

Hamad Med Corp Hamad Gen Hosp Dept Med Doha Qatar;

Hamad Med Corp Hamad Gen Hosp Dept Med Doha Qatar;

Hamad Med Corp Hamad Gen Hosp Dept Med Doha Qatar;

Hamad Med Corp Hamad Gen Hosp Dept Virol Doha Qatar;

Hamad Med Corp Communicable Dis Ctr Dept Infect Dis Doha Qatar;

Hamad Med Corp Hamad Gen Hosp Dept Med Doha Qatar;

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正文语种 eng
中图分类地方病学;
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Case Report: Prolonged Viral Shedding in Six COVID-19 Patients

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