• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry >Clinical and MRI Predictors of Conversion From Mild Behavioural to Dementia
【24h】

Clinical and MRI Predictors of Conversion From Mild Behavioural to Dementia

机译：从轻度行为对痴呆症转化的临床和MRI预测因子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: As an analogy with mild cognitive impairment (MCI), the mild behavioral impairment (MBI) construct has been proposed as a diagnostic label for those presenting late -onset behavioral symptoms. To date, however, the clinical, cognitive, and structural imaging features associated with an increased risk of conversion from MBI to dementia are poorly understood. Methods: We retrospectively analyzed the cognitive performance and struc- tural brain MRI of 113 subjects, with a clinical follow-up of at least 4 years available. Subjects were randomly assigned to a Group A (56 subjects; age: 65.4 +/- 7.9 years, 15 females, MMSE score: 28.4 +/- 2.3)) or to a Group B (57 subjects, age: 66.6 +/- 6.4, 17 females, MMSE score: 28.0 +/- 1.4). In the Group A, cognitive and structural variables were compared between converters (at 4 years) and nonconverters and then verified in the Group B group. Results: In the Group A, 14 patients converted to behavioral -variant of frontotemporal dementia (bv-FTD) and 4 to Alzheimer's Disease (AD). Converters presented at baseline lower executive function scores and total Theory of Mind (ToM scores), as well as more severe focal frontal atrophy. In the Group B, 13 sub- jects converted to bv-FTD and none to AD. The combination of the variables identified in the Group A significantly (p < 0.001) discriminated between con- verters and nonconverters in the Group B with a sensitivity of 0.615 and a specificity of 1 (total accuracy 91.22%). Conclusion: The combined presence of executive deficit, impaired ToM, and presence of isolated frontal atrophy was associated with risk of progression from MBI to a clinically evident neurodegenerative condition, mainly bv-FTD, over a 4-year period.
机译：目的：作为与轻度认知损伤（MCI）的类比，轻度行为损伤（MBI）结构被提出作为晚发行为症状患者的诊断标签。然而，到目前为止，与从MBI转化为痴呆的风险增加相关的临床、认知和结构成像特征尚不清楚。方法：我们回顾性分析了113名受试者的认知能力和脑结构MRI，并进行了至少4年的临床随访。受试者被随机分配到a组（56名受试者；年龄：65.4+/-7.9岁，15名女性，MMSE评分：28.4+/-2.3））或B组（57名受试者，年龄：66.6+/-6.4，17名女性，MMSE评分：28.0+/-1.4）。在A组中，对转化者（4岁时）和非转化者之间的认知和结构变量进行比较，然后在B组中进行验证。结果：在A组中，14名患者转为行为变异型额颞叶痴呆（bv FTD），4名转为阿尔茨海默病（AD）。在基线检查时，患者的执行功能评分和总体心理理论（ToM评分）较低，以及更严重的局灶性额叶萎缩。在B组中，13名受试者转化为bv FTD，无一人转化为AD。A组中确定的变量组合显著（p<0.001）区分了B组中的转化者和非转化者，敏感性为0.615，特异性为1（总准确率91.22%）。结论：执行缺陷、ToM受损和孤立性额叶萎缩的合并存在与4年内从MBI进展为临床明显的神经退行性疾病（主要是bv FTD）的风险相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号