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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Lower plasma vascular endothelial growth factor A in major depressive disorder not normalized after antidepressant treatment: A case control study
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Lower plasma vascular endothelial growth factor A in major depressive disorder not normalized after antidepressant treatment: A case control study

机译：降低血浆血管内皮生长因子A在抗抑郁治疗后未归一化的主要抑郁症：案例对照研究

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Objective: Vascular endothelial growth factor A is a growth factor with pro-angiogenic and neurotrophic properties. Anti-vascular endothelial growth factor A treatments, used to treat cancers and opthalmic diseases, are known to induce depressive symptoms. Thus, we hypothesized that vascular endothelial growth factor A plasma levels are low in patients experiencing a major depressive episode in the context of major depressive disorder, which consequently increase after antidepressant treatment. The aim of this study was to compare plasma vascular endothelial growth factor A levels in patients with major depressive episode-major depressive disorder before and after antidepressant treatment. Methods: Vascular endothelial growth factor A fasting plasma levels of 469 major depressive episode-major depressive disorder patients were compared with healthy controls. Depressed patients were assessed for remission after 3 and 6 months of antidepressant treatment. Bivariate and multivariate analyses adjusted for sex, age, body mass index and tobacco use were performed. Results: As compared to healthy controls, major depressive episode patients had lower vascular endothelial growth factor A, 66.0 (38.3) pg/mL (standard deviation) vs 83.2 (49.2) pg/mL, p < 0.0001. Plasma vascular endothelial growth factor A levels did not change after antidepressant treatment, even in remitters, and remained lower than those of healthy controls, 64.9 (39.3) pg/mL vs 83.2 (49.2) pg/mL, p < 0.0001. Conclusion: Depressed patients with major depressive disorder have lower plasma vascular endothelial growth factor A levels than healthy controls during their major depressive episode and after remission following antidepressant treatment. New strategies targeting enhancement of plasma vascular endothelial growth factor A could be promising for the prevention and treatment of major depressive disorder.
机译：目的：血管内皮生长因子A是一种具有促血管生成和神经营养特性的生长因子。抗血管内皮生长因子A治疗用于治疗癌症和眼科疾病，已知会诱发抑郁症状。因此，我们假设，在重度抑郁症患者中，血管内皮生长因子A的血浆水平较低，因此在抗抑郁剂治疗后会升高。本研究的目的是比较重度抑郁症患者在抗抑郁治疗前后的血浆血管内皮生长因子A水平。方法：对469例抑郁症患者的血管内皮生长因子A空腹血浆水平与健康对照组进行比较。抑郁患者在接受抗抑郁药治疗3个月和6个月后进行病情缓解评估。对性别、年龄、体重指数和烟草使用进行了双变量和多变量分析。结果：与健康对照组相比，重度抑郁发作患者的血管内皮生长因子A水平较低，分别为66.0（38.3）pg/mL（标准差）和83.2（49.2）pg/mL，p<0.0001。抗抑郁药治疗后，血浆血管内皮生长因子A水平没有变化，即使在缓解者中也是如此，并且仍然低于健康对照组，分别为64.9（39.3）pg/mL和83.2（49.2）pg/mL，p<0.0001。结论：抑郁症患者在抑郁症发作期间及抗抑郁药物治疗后缓解后的血浆血管内皮生长因子A水平低于健康对照组。针对增强血浆血管内皮生长因子A的新策略有望用于预防和治疗重度抑郁症。

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