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首页> 外文期刊>Brain research bulletin >Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study
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Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study

机译：抑郁症患者睡眠剥夺时抗抑郁药的快速变化与血管内皮生长因子（VEGF）的变化有关：一项先导研究

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摘要

While conventional antidepressants benefit many patients with major depressive disorder (MDD), as much as eight to 12 weeks can elapse before significant improvements in depressive symptoms are seen. Treatments that act more rapidly in MDD are urgently needed. Sleep deprivation (SD) has been shown to produce a rapid antidepressant response within one day in 50-60% of patients with MDD; thus, identifying its antidepressant mechanism may contribute to the development of antidepressants that act more rapidly. The present study evaluated the effects of 39. h of SD on mood, as well as on plasma levels of brain derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in patients with MDD. After a drug-free period of at least two weeks, 11 patients (6 males, 5 females; ages 25-62) who met DSM-IV criteria for MDD underwent total SD. Plasma samples for BDNF and VEGF assays were collected on Days 1 (baseline) and 2. The six-item Hamilton Rating Scale for Depression (HAMD-6) was the primary outcome measure. HAMD-6 scores decreased significantly after SD (Day 2). SD was negatively correlated with change in HAMD-6 score and change in VEGF levels, indicating that as depression scores decreased following SD, VEGF plasma levels increased. In contrast, SD did not alter plasma BDNF concentrations, nor was an association found between BDNF levels and clinical improvement on the HAMD-6. These results suggest that SD is associated with mood-related changes in plasma VEGF levels, but not plasma BDNF levels. Further studies using larger sample sizes are needed to confirm these preliminary findings.
机译：尽管传统的抗抑郁药使许多重度抑郁症患者受益，但在抑郁症状得到明显改善之前，可能需要长达8至12周的时间。迫切需要在MDD中起更快作用的治疗。研究表明，在50-60％的MDD患者中，睡眠剥夺（SD）会在一天之内产生快速的抗抑郁反应。因此，确定其抗抑郁机制可能有助于发展起更快作用的抗抑郁药。本研究评估了39.h SD对MDD患者情绪以及脑源性神经营养因子（BDNF）和血管内皮生长因子（VEGF）血浆水平的影响。在至少两周的无药期后，对符合DSM-IV MDD标准的11例患者（男6例，女5例;年龄25-62岁）进行了总SD。在第1天（基线）和第2天收集用于BDNF和VEGF测定的血浆样品。六项汉密尔顿抑郁量表（HAMD-6）是主要的结局指标。 SD后（第2天），HAMD-6分数显着下降。 SD与HAMD-6评分的变化和VEGF水平的变化呈负相关，表明随着SD抑郁评分的降低，VEGF血浆水平也随之升高。相反，SD并未改变血浆BDNF浓度，也未发现BDNF水平与HAMD-6的临床改善之间存在关联。这些结果表明SD与血浆VEGF水平的情绪相关变化有关，但与血浆BDNF水平无关。需要使用更大样本量的进一步研究来确认这些初步发现。

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