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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Disruptive mood dysregulation disorder, severe mood dysregulation and chronic irritability in youth at high familial risk of bipolar disorder
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Disruptive mood dysregulation disorder, severe mood dysregulation and chronic irritability in youth at high familial risk of bipolar disorder

机译：颠覆性情绪失调障碍，在双相障碍的高处理风险中严重情绪失调和青年慢性烦躁和慢性烦躁

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Objective: Disruptive mood dysregulation disorder is a newly proposed childhood disorder included in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition to describe children ?18 years of age with chronic irritability/temper outbursts. This study aimed to examine the prevalence of disruptive mood dysregulation disorder, severe mood dysregulation and chronic irritability in an Australian study of young people at increased familial risk of developing bipolar disorder (‘HR’ group) and controls (‘CON’ group). Methods: A total of 242 12- to 30-year-old HR or CON subjects were administered the severe mood dysregulation module. Of these, 42 were aged ?18 years at the time of assessment, with 29 subjects in the HR group and 13 in the CON group. Results: No subjects ?18 years – in either group – fulfilled current or lifetime criteria for disruptive mood dysregulation disorder or severe mood dysregulation, the precursor to disruptive mood dysregulation disorder. Similarly, no subjects in either group endorsed the severe mood dysregulation/disruptive mood dysregulation disorder criteria for irritable mood or marked excessive reactivity. One HR participant endorsed three severe mood dysregulation criteria (distractibility, physical restlessness and intrusiveness), while none of the comparison subjects endorsed any criteria. Exploratory studies of the broader 12- to 30-year-old sample similarly found no subjects with severe mood dysregulation/disruptive mood dysregulation disorder in either the HR or CON group and no increased rates of chronic irritability, although significantly more HR subjects reported at least one severe mood dysregulation/disruptive mood dysregulation disorder criterion (likelihood ratio = 6.17; p = 0.013); most of the reported criteria were severe mood dysregulation ‘chronic hyper-arousal’ symptoms. Conclusion: This study comprises one of the few non-US reports on the prevalence of disruptive mood dysregulation disorder and severe mood dysregulation and is the first non-US study of the prevalence of these conditions in a high-risk bipolar disorder sample. The failure to replicate the finding of higher rates of disruptive mood dysregulation disorder and chronic irritability in high-risk offspring suggests that these are not robust precursors of bipolar disorder.
机译：目的：破坏性情绪调节障碍是一种新提出的儿童障碍，被纳入《精神障碍诊断和统计手册》第五版，用于描述儿童？18岁，患有慢性易怒/脾气爆发。本研究旨在调查澳大利亚一项研究中破坏性情绪调节障碍、严重情绪调节障碍和慢性易怒的患病率，该研究针对的是患双相情感障碍家族风险增加的年轻人（“HR”组）和对照组（“CON”组）。方法：共有242名12至30岁的HR或CON受试者接受了严重情绪调节障碍模块。其中42人年龄？评估时为18年，HR组29名受试者，CON组13名受试者。结果：没有受试者？18年——在任何一组中——都符合破坏性情绪调节障碍或严重情绪调节障碍的当前或终生标准，这是破坏性情绪调节障碍的前兆。类似地，两组中均没有受试者支持严重情绪调节障碍/破坏性情绪调节障碍标准，即易怒情绪或明显的过度反应。一名HR参与者支持三个严重的情绪调节障碍标准（分心、身体不安和干扰），而对照受试者均不支持任何标准。对更广泛的12至30岁样本进行的探索性研究同样发现，HR或CON组均未出现严重情绪调节障碍/破坏性情绪调节障碍的受试者，且慢性易怒率也没有增加，尽管明显有更多的HR受试者报告了至少一个严重情绪调节障碍/破坏性情绪调节障碍标准（似然比=6.17；p=0.013）；大多数报告的标准是严重的情绪调节障碍“慢性高觉醒”症状。结论：这项研究是关于破坏性情绪调节障碍和严重情绪调节障碍患病率的少数非美国报告之一，也是第一项关于高危双相情感障碍样本中这些疾病患病率的非美国研究。未能复制高风险后代更高比例的破坏性情绪调节障碍和慢性易怒的发现表明，这些并不是双相情感障碍的有力先兆。

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