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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Reduced activation of the ventromedial prefrontal cortex during self-referential processing in individuals at ultra-high risk for psychosis
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Reduced activation of the ventromedial prefrontal cortex during self-referential processing in individuals at ultra-high risk for psychosis

机译：在近高风险的个体心理学中的自我参照处理中减少了腹侧前额叶皮质的激活

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Objective: Defects in self-referential processing and perspective-taking are core characteristics that may underlie psychotic symptoms and impaired social cognition in schizophrenia. Here, we investigated the neural correlates of self-referential processing regardless of the perspective taken and third-person perspective-taking regardless of the target person to judge relevance in individuals at ultra-high risk for psychosis. We also explored relationships between alterations in neural activity and neurocognitive function and basic self ('ipseity') disorder. Methods: Twenty-two ultra-high-risk individuals and 28 healthy controls completed a functional magnetic resonance imaging task. While being scanned, participants were asked to take a first-person perspective or to put themselves in their close relative's place thereby adopting a third-person perspective during judgments of the relevance of personality trait adjectives to one's self and a close relative. Results: For self-referential (vs other-referential) processing, ultra-high-risk individuals showed less neural activity in the left ventromedial prefrontal cortex/medial orbitofrontal cortex, which was correlated with poor working memory performance. When taking a third-person perspective (vs first-person perspective), ultra-high-risk individuals showed more activity in the middle occipital gyrus. Conclusion: Taken together, our findings suggest that ultra-high-risk individuals already show aberrant neural activity during self-referential processing which may possibly be related to engagement of working memory resources.
机译：目的：自我参照加工和视角选择的缺陷是精神分裂症患者精神病性症状和社会认知受损的核心特征。在这里，我们研究了自我参照加工的神经相关因素，无论采用何种视角，以及第三人称视角，无论目标人如何，以判断精神病超高风险个体的相关性。我们还探讨了神经活动和神经认知功能的改变与基本自我（“自我认同”）障碍之间的关系。方法：22名超高危人群和28名健康对照完成功能性磁共振成像任务。在接受扫描时，参与者被要求采取第一人称视角，或者站在近亲的立场，从而在判断人格特质形容词与自己和近亲的相关性时采用第三人称视角。结果：对于自我参照（相对于其他参照）处理，超高风险个体的左腹内侧前额叶皮质/内侧眶额皮质的神经活动较少，这与工作记忆表现不佳有关。当采用第三人称视角（相对于第一人称视角）时，超高风险个体在枕中回表现出更多的活动。结论：综上所述，我们的研究结果表明，超高风险个体在自我参照加工过程中已经表现出异常的神经活动，这可能与工作记忆资源的使用有关。

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