...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavioural Brain Research: An International Journal >Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism.
【24h】

Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism.

机译：与新生博尔纳病病毒感染的Lewis大鼠异常的游戏行为相关的发育性脑损伤：一种自闭症模型。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Play behavior, nonsocial exploratory activity, and nonplay social interaction were observed in male juvenile Lewis rats with brain developmental injury following neonatal infection with Borna disease virus (BDV). These behaviors were tested using the 'intruder-resident' paradigm, with social isolation of residents for six days prior to testing. Four experimental pairings of infected (BDV) and uninfected (NL) rats were studied as follows: NL-NL; NL BDV; BDV NL; and BDV-BDV (the first member is the resident, the second member is the intruder). Observation of social activities was carried out for 10 min on two consecutive days. Nonsocial exploratory activity (e.g. ambulation and rearing) was similar in BDV and NL residents. Duration of nonplay social investigation (e.g. sniffing, approach, and follow) was higher in BDV residents as compared to NL residents when tested on the first test day. On the second day, all rats showed similar level of nonplay social interaction. When confronted with NL intruders, NL residents exhibited significantly more play behavior compared to the NL-BDV, BDV NL and BDV-BDV pairs, when play behavior was measured by the number of 'pins'. Moreover, irrespective of a type of intruder, NL residents demonstrated higher play soliciting behavior than BDV residents, indicating attenuated readiness to play in BDV-infected rats. The number of pins and play solicitations in BDV-NL pairs significantly increased over the two days of testing, while play activity in NL-BDV pairs declined on the second test day. This pattern suggests that the degree of social reinforcement on the first day of testing affected the level of play on the second day. These data demonstrate deficits in play behavior and other social interactions following BDV-associated developmental brain injury, thus supporting the value of the neonatally BDV-infected rat as an animal model of autism.
机译：在新生儿感染博尔纳病病毒（BDV）后，患有脑发育损伤的雄性路易斯青少年雄性大鼠中观察到了游戏行为，非社交探索活动和非游戏社交互动。使用“入侵者-居民”范式对这些行为进行了测试，并在测试前六天对居民进行了社会隔离。感染（BDV）和未感染（NL）大鼠的四个实验配对研究如下：NL-NL; NL BDV; BDV NL; BDV-BDV（第一个成员是居民，第二个成员是入侵者）。连续两天进行了10分钟的社交活动观察。 BDV和NL居民的非社交探索活动（例如，步行和抚养）相似。在第一个测试日进行测试时，BDV居民的非游戏社会调查（例如嗅探，进近和追踪）持续时间比NL居民长。在第二天，所有大鼠表现出相似的非游戏社交互动水平。与NL-BDV，BDV NL和BDV-BDV对相比，当面对NL入侵者时，NL居民表现出明显更多的游戏行为，而后者是通过“引脚”的数量来衡量的。而且，不管入侵者的类型如何，NL居民表现出的游戏拉客行为都比BDV居民高，这表明受BDV感染的大鼠的游戏准备就绪度降低。在测试的两天内，BDV-NL对中的插针和游戏请求数量显着增加，而NL-BDV对中的游戏活动在第二个测试日下降。这种模式表明测试第一天的社交增强程度会影响第二天的游戏水平。这些数据表明与BDV相关的发育性脑损伤后游戏行为和其他社交互动方面的缺陷，从而支持了新生儿BDV感染大鼠作为自闭症动物模型的价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号