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首页> 外文期刊>The European Journal of Neuroscience >The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review
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The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review

机译：COMT RS4680对健康成年人功能连通性的影响：系统评价

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摘要

The aim of this systematic review was to qualitatively synthesise the available research that investigated the influence of COMT genotype at SNP rs4680 on both task-based and resting-state connectivity in healthy adults. Thirty-five studies were identified that met inclusion criteria. Of the included studies, 20 studies reported resting-state findings and 16 studies reported task-based findings (emotion-processing, memory, working memory, reward-based learning and executive function). Studies were highly heterogeneous but an overall trend towards an association of the Val allele with greater resting-state connectivity and the Met allele with greater task-based connectivity is reported. A possible interpretation of current findings is discussed, whereby the Val allele is associated with improved cognitive flexibility allowing integration of novel relevant stimuli, and the Met allele allows improved sustained attention and targeted neural processing, particularly between limbic regions and prefrontal cortex. The most promising brain regions implicated in a COMT genotype influence on functional connectivity include prefrontal regions, amygdala and hippocampus.
机译：本系统综述的目的是定性地综合现有研究，研究SNP rs4680的COMT基因型对健康成年人基于任务和静息状态连通性的影响。共有35项研究符合纳入标准。在纳入的研究中，20项研究报告了静息状态的发现，16项研究报告了基于任务的发现（情绪处理、记忆、工作记忆、基于奖励的学习和执行功能）。研究具有高度异质性，但有报道称，Val等位基因与更大的静息状态连通性和Met等位基因与更大的基于任务的连通性之间存在关联。本文讨论了对当前发现的一种可能解释，即Val等位基因与认知灵活性的提高相关，允许整合新的相关刺激，而Met等位基因允许改善持续注意力和定向神经处理，尤其是边缘区和前额叶皮质之间的持续注意和定向神经处理。COMT基因型对功能连通性影响最有希望的大脑区域包括前额叶区域、杏仁核和海马。

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